Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits Export

@article{citeulike:464431, abstract = {Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from {gamma}-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon.}, author = {Szabadics, Janos and Varga, Csaba and Molnar, Gabor and Olah, Szabolcs and Barzo, Pal and Tamas, Gabor}, citeulike-article-id = {464431}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1121325}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/311/5758/233}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16410524}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16410524}, day = {13}, doi = {10.1126/science.1121325}, journal = {Science}, keywords = {axo-axonique, chandelier}, month = {January}, number = {5758}, pages = {233--235}, posted-at = {2008-08-11 15:41:59}, priority = {2}, title = {Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits}, url = {http://dx.doi.org/10.1126/science.1121325}, volume = {311}, year = {2006} }

TY - JOUR ID - citeulike:464431 L3 - citeulike-article-id:464431 N2 - Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from {gamma}-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon. IS - 5758 JF - Science EP - 235 TI - Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits VL - 311 SP - 233 KW - axo-axonique KW - chandelier AU - Szabadics, Janos AU - Varga, Csaba AU - Molnar, Gabor AU - Olah, Szabolcs AU - Barzo, Pal AU - Tamas, Gabor PY - 2006/01/13/ UR - http://dx.doi.org/10.1126/science.1121325 ER -