Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition. Export

@article{citeulike:4681095, abstract = {Neurons recruited for local computations exhibit rhythmic activity at gamma frequencies. The amplitude and frequency of these oscillations are continuously modulated depending on stimulus and behavioral state. This modulation is believed to crucially control information flow across cortical areas. Here we report that in the rat hippocampus gamma oscillation amplitude and frequency vary rapidly, from one cycle to the next. Strikingly, the amplitude of one oscillation predicts the interval to the next. Using in vivo and in vitro whole-cell recordings, we identify the underlying mechanism. We show that cycle-by-cycle fluctuations in amplitude reflect changes in synaptic excitation spanning over an order of magnitude. Despite these rapid variations, synaptic excitation is immediately and proportionally counterbalanced by inhibition. These rapid adjustments in inhibition instantaneously modulate oscillation frequency. So, by rapidly balancing excitation with inhibition, the hippocampal network is able to swiftly modulate gamma oscillations over a wide band of frequencies.}, author = {Atallah, Bassam V. and Scanziani, Massimo}, citeulike-article-id = {4681095}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2009.04.027}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627309003511}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19477157}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19477157}, day = {28}, doi = {10.1016/j.neuron.2009.04.027}, issn = {1097-4199}, journal = {Neuron}, keywords = {excitatory, gamma, hippocampe, inhibitory, jocl}, month = {May}, number = {4}, pages = {566--577}, posted-at = {2009-07-19 14:39:12}, priority = {2}, title = {Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition.}, url = {http://dx.doi.org/10.1016/j.neuron.2009.04.027}, volume = {62}, year = {2009} }

TY - JOUR ID - citeulike:4681095 L3 - citeulike-article-id:4681095 N2 - Neurons recruited for local computations exhibit rhythmic activity at gamma frequencies. The amplitude and frequency of these oscillations are continuously modulated depending on stimulus and behavioral state. This modulation is believed to crucially control information flow across cortical areas. Here we report that in the rat hippocampus gamma oscillation amplitude and frequency vary rapidly, from one cycle to the next. Strikingly, the amplitude of one oscillation predicts the interval to the next. Using in vivo and in vitro whole-cell recordings, we identify the underlying mechanism. We show that cycle-by-cycle fluctuations in amplitude reflect changes in synaptic excitation spanning over an order of magnitude. Despite these rapid variations, synaptic excitation is immediately and proportionally counterbalanced by inhibition. These rapid adjustments in inhibition instantaneously modulate oscillation frequency. So, by rapidly balancing excitation with inhibition, the hippocampal network is able to swiftly modulate gamma oscillations over a wide band of frequencies. IS - 4 JF - Neuron SN - 1097-4199 EP - 577 TI - Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition. VL - 62 SP - 566 KW - excitatory KW - gamma KW - hippocampe KW - inhibitory KW - jocl AU - Atallah, Bassam AU - Scanziani, Massimo PY - 2009/05/28/ UR - http://dx.doi.org/10.1016/j.neuron.2009.04.027 ER -