Ca2+-activated K+ (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. Export

@article{citeulike:6070437, abstract = {In many neurons, trains of action potentials show frequency-dependent broadening. This broadening results from the voltage-dependent inactivation of K+ currents that contribute to action potential repolarisation. In different neuronal cell types these K+ currents have been shown to be either slowly inactivating delayed rectifier type currents or rapidly inactivating A-type voltage-gated K+ currents. Recent findings show that inactivation of a Ca2+-dependent K+ current, mediated by large conductance BK-type channels, also contributes to spike broadening. Here, using whole-cell recordings in acute slices, we examine spike broadening in lateral amygdala projection neurons. Spike broadening is frequency dependent and is reversed by brief hyperpolarisations. This broadening is reduced by blockade of voltage-gated Ca2+ channels and BK channels. In contrast, broadening is not blocked by high concentrations of 4-aminopyridine (4-AP) or alpha-dendrotoxin. We conclude that while inactivation of BK-type Ca2+-activated K+ channels contributes to spike broadening in lateral amygdala neurons, inactivation of another as yet unidentified outward current also plays a role.}, author = {Faber, Louise S. and Sah, Pankaj}, citeulike-article-id = {6070437}, citeulike-linkout-0 = {http://dx.doi.org/10.1113/jphysiol.2003.050120}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14561831}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14561831}, day = {15}, doi = {10.1113/jphysiol.2003.050120}, issn = {0022-3751}, journal = {The Journal of physiology}, keywords = {bk\_channels, electrophysiologiqpropriete}, month = {October}, number = {Pt 2}, pages = {483--497}, posted-at = {2009-11-04 16:52:02}, priority = {2}, title = {Ca2+-activated K+ (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala.}, url = {http://dx.doi.org/10.1113/jphysiol.2003.050120}, volume = {552}, year = {2003} }

TY - JOUR ID - citeulike:6070437 L3 - citeulike-article-id:6070437 N2 - In many neurons, trains of action potentials show frequency-dependent broadening. This broadening results from the voltage-dependent inactivation of K+ currents that contribute to action potential repolarisation. In different neuronal cell types these K+ currents have been shown to be either slowly inactivating delayed rectifier type currents or rapidly inactivating A-type voltage-gated K+ currents. Recent findings show that inactivation of a Ca2+-dependent K+ current, mediated by large conductance BK-type channels, also contributes to spike broadening. Here, using whole-cell recordings in acute slices, we examine spike broadening in lateral amygdala projection neurons. Spike broadening is frequency dependent and is reversed by brief hyperpolarisations. This broadening is reduced by blockade of voltage-gated Ca2+ channels and BK channels. In contrast, broadening is not blocked by high concentrations of 4-aminopyridine (4-AP) or alpha-dendrotoxin. We conclude that while inactivation of BK-type Ca2+-activated K+ channels contributes to spike broadening in lateral amygdala neurons, inactivation of another as yet unidentified outward current also plays a role. IS - Pt 2 JF - The Journal of physiology SN - 0022-3751 EP - 497 TI - Ca2+-activated K+ (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. VL - 552 SP - 483 KW - bk_channels KW - electrophysiologiqpropriete AU - Faber, Louise AU - Sah, Pankaj PY - 2003/10/15/ UR - http://dx.doi.org/10.1113/jphysiol.2003.050120 ER -