Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Export

@article{citeulike:937990, abstract = {Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.}, address = {Molecular Neurobiology, Department of Biology-Chemistry-Pharmacy, Freie Universit\"{a}t Berlin, 14195 Berlin, Germany; Center for Molecular Neurobiology, 20251 Hamburg, Germany.}, author = {Plath, N. and Ohana, O. and Dammermann, B. and Errington, M. L. and Schmitz, D. and Gross, C. and Mao, X. and Engelsberg, A. and Mahlke, C. and Welzl, H. and Kobalz, U. and Stawrakakis, A. and Fernandez, E. and Waltereit, R. and Bick-Sander, A. and Therstappen, E. and Cooke, S. F. and Blanquet, V. and Wurst, W. and Salmen, B. and B\"{o}sl, M. R. and Lipp, H. P. and Grant, S. G. and Bliss, T. V. and Wolfer, D. P. and Kuhl, D.}, citeulike-article-id = {937990}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2006.08.024}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17088210}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17088210}, day = {9}, doi = {10.1016/j.neuron.2006.08.024}, issn = {0896-6273}, journal = {Neuron}, keywords = {arc, consolidation, ko, memoire, plasticity}, month = {November}, number = {3}, pages = {437--444}, posted-at = {2007-09-27 11:11:45}, priority = {2}, title = {Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.}, url = {http://dx.doi.org/10.1016/j.neuron.2006.08.024}, volume = {52}, year = {2006} }

TY - JOUR ID - citeulike:937990 L3 - citeulike-article-id:937990 N2 - Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage. IS - 3 JF - Neuron SN - 0896-6273 AD - Molecular Neurobiology, Department of Biology-Chemistry-Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany; Center for Molecular Neurobiology, 20251 Hamburg, Germany. EP - 444 TI - Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. VL - 52 SP - 437 KW - arc KW - consolidation KW - ko KW - memoire KW - plasticity AU - Plath, N AU - Ohana, O AU - Dammermann, B AU - Errington, ML AU - Schmitz, D AU - Gross, C AU - Mao, X AU - Engelsberg, A AU - Mahlke, C AU - Welzl, H AU - Kobalz, U AU - Stawrakakis, A AU - Fernandez, E AU - Waltereit, R AU - Bick-Sander, A AU - Therstappen, E AU - Cooke, SF AU - Blanquet, V AU - Wurst, W AU - Salmen, B AU - Bösl, MR AU - Lipp, HP AU - Grant, SG AU - Bliss, TV AU - Wolfer, DP AU - Kuhl, D PY - 2006/11/09/ UR - http://dx.doi.org/10.1016/j.neuron.2006.08.024 ER -