AP-1 in mouse development and tumorigenesis. Export

@article{citeulike:910330, abstract = {Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles of AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis.}, address = {Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.}, author = {Jochum, W. and Passegu\'{e}, E. and Wagner, E. F.}, citeulike-article-id = {910330}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.onc.1204389}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11402336}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11402336}, day = {30}, doi = {10.1038/sj.onc.1204389}, issn = {0950-9232}, journal = {Oncogene}, keywords = {ap-1, development, mouse, tumorigenesis}, month = {April}, number = {19}, pages = {2401--2412}, posted-at = {2006-10-23 17:50:30}, priority = {2}, title = {AP-1 in mouse development and tumorigenesis.}, url = {http://dx.doi.org/10.1038/sj.onc.1204389}, volume = {20}, year = {2001} }

TY - JOUR ID - citeulike:910330 L3 - citeulike-article-id:910330 N2 - Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles of AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis. IS - 19 JF - Oncogene SN - 0950-9232 AD - Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. EP - 2412 TI - AP-1 in mouse development and tumorigenesis. VL - 20 SP - 2401 KW - ap-1 KW - development KW - mouse KW - tumorigenesis AU - Jochum, W AU - Passegué, E AU - Wagner, EF PY - 2001/04/30/ UR - http://dx.doi.org/10.1038/sj.onc.1204389 ER -