Self-assembling peptides as injectable lubricants for osteoarthritis

@article{citeulike:970583, abstract = {The self-assembly of peptides is explored as an alternative route towards the development of new injectable joint lubricants for osteoarthritis (OA). The versatility of the peptide chemistry allows the incorporation of behavior reminiscent of hyaluronic acid (HA), while the triggered in situ self-assembly provides easy delivery of the samples by injection due to the low viscosity of the peptide solutions (that are initially monomeric). Using design criteria based on the chemical properties of HA, a range of de novo peptides were prepared with systematic alterations of charge and hydrophilicity that self-assembled into nematic fluids and gels in physiological solution conditions. The frictional characteristics of the peptides were evaluated using cartilage on cartilage sliding contacts along with their rheological characteristics. Peptide P11-9, whose molecular, mesoscopic, and rheological properties most closely resembled HA was found to be the most effective lubricant amongst the peptides. In healthy static and dynamic friction testing (corresponding to healthy joints) P11-9 at 20-40 mg/mL performed similar to HA at 10 mg/mL. In friction tests with damaged cartilage (corresponding to early stage OA) P11-9 was a less efficient lubricant than HA, but still the best among all the peptides tested. The results indicate that de novo self-assembling peptides could be developed as an alternate therapeutic lubricant for early stage OA. {\copyright} 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006}, address = {Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom; Centre for Self-Organising Molecular Systems, School of Chemistry, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom; School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom}, author = {Bell, Carol J. and Carrick, Lisa M. and Katta, Jayanth and Jin, Zhongmin and Ingham, Eileen and Aggeli, Amalia and Boden, Neville and Waigh, Thomas A. and Fisher, John }, citeulike-article-id = {970583}, doi = {http://dx.doi.org/10.1002/jbm.a.30672}, journal = {Journal of Biomedical Materials Research Part A}, number = {2}, pages = {236--246}, posted-at = {2006-12-01 16:34:26}, priority = {2}, title = {Self-assembling peptides as injectable lubricants for osteoarthritis}, url = {http://dx.doi.org/10.1002/jbm.a.30672}, volume = {78A}, year = {2006} }

TY - JOUR ID - citeulike:970583 L3 - citeulike-article-id:970583 TI - Self-assembling peptides as injectable lubricants for osteoarthritis JF - Journal of Biomedical Materials Research Part A VL - 78A IS - 2 SP - 236 EP - 246 AD - Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom; Centre for Self-Organising Molecular Systems, School of Chemistry, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom; School of Physics and Astronomy, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom N2 - The self-assembly of peptides is explored as an alternative route towards the development of new injectable joint lubricants for osteoarthritis (OA). The versatility of the peptide chemistry allows the incorporation of behavior reminiscent of hyaluronic acid (HA), while the triggered in situ self-assembly provides easy delivery of the samples by injection due to the low viscosity of the peptide solutions (that are initially monomeric). Using design criteria based on the chemical properties of HA, a range of de novo peptides were prepared with systematic alterations of charge and hydrophilicity that self-assembled into nematic fluids and gels in physiological solution conditions. The frictional characteristics of the peptides were evaluated using cartilage on cartilage sliding contacts along with their rheological characteristics. Peptide P11-9, whose molecular, mesoscopic, and rheological properties most closely resembled HA was found to be the most effective lubricant amongst the peptides. In healthy static and dynamic friction testing (corresponding to healthy joints) P11-9 at 20-40 mg/mL performed similar to HA at 10 mg/mL. In friction tests with damaged cartilage (corresponding to early stage OA) P11-9 was a less efficient lubricant than HA, but still the best among all the peptides tested. The results indicate that de novo self-assembling peptides could be developed as an alternate therapeutic lubricant for early stage OA. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006 AU - Bell, Carol AU - Carrick, Lisa AU - Katta, Jayanth AU - Jin, Zhongmin AU - Ingham, Eileen AU - Aggeli, Amalia AU - Boden, Neville AU - Waigh, Thomas AU - Fisher, John PY - 2006/// UR - http://dx.doi.org/10.1002/jbm.a.30672 ER -