Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression Export

@article{citeulike:3924604, abstract = {We present an analytical framework describing the steady-state distribution of protein concentration in live cells, considering that protein production occurs in random bursts with an exponentially distributed number of molecules. We extend this framework for cases of transcription autoregulation and noise propagation in a simple genetic network. This model allows for the extraction of kinetic parameters of gene expression from steady-state distributions of protein concentration in a cell population, which are available from single cell data obtained by flow cytometry or fluorescence microscopy.}, author = {Friedman, Nir and Cai, Long and Xie, X. Sunney}, citeulike-article-id = {3924604}, citeulike-linkout-0 = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000097000016168302000001&idtype=cvips&gifs=yes}, citeulike-linkout-1 = {http://link.aps.org/abstract/PRL/v97/e168302}, citeulike-linkout-2 = {http://dx.doi.org/10.1103/PhysRevLett.97.168302}, doi = {10.1103/PhysRevLett.97.168302}, journal = {Physical Review Letters}, keywords = {genetics, single-cell, stochasticity}, number = {16}, pages = {168302+}, posted-at = {2009-09-25 14:33:21}, priority = {2}, publisher = {APS}, title = {Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression}, url = {http://dx.doi.org/10.1103/PhysRevLett.97.168302}, volume = {97}, year = {2006} }

TY - JOUR ID - citeulike:3924604 L3 - citeulike-article-id:3924604 N2 - We present an analytical framework describing the steady-state distribution of protein concentration in live cells, considering that protein production occurs in random bursts with an exponentially distributed number of molecules. We extend this framework for cases of transcription autoregulation and noise propagation in a simple genetic network. This model allows for the extraction of kinetic parameters of gene expression from steady-state distributions of protein concentration in a cell population, which are available from single cell data obtained by flow cytometry or fluorescence microscopy. IS - 16 JF - Physical Review Letters TI - Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression PB - APS VL - 97 SP - 168302 KW - genetics KW - single-cell KW - stochasticity AU - Friedman, Nir AU - Cai, Long AU - Xie, Sunney PY - 2006/// UR - http://dx.doi.org/10.1103/PhysRevLett.97.168302 ER -