Genetics of Crohn disease, an archetypal inflammatory barrier disease Export

@article{Schreiber2005, abstract = {Chronic inflammatory disorders such as Crohn disease, atopic eczema, asthma and psoriasis are triggered by hitherto unknown environmental factors that function on the background of some polygenic susceptibility. Recent technological advances have allowed us to unravel the genetic aetiology of these and other complex diseases. Using Crohn disease as an example, we show how the discovery of susceptibility genes furthers our understanding of the underlying disease mechanisms and how it will, ultimately, give rise to new therapeutic developments. The long-term goal of such endeavours is to develop targeted prophylactic strategies. These will probably target the molecular interaction on the mucosal surface between the products of the genome and the microbial metagenome of a patient.}, author = {Schreiber, Stefan and Rosenstiel, Philip and Albrecht, Mario and Hampe, Jochen and Krawczak, Michael}, citeulike-article-id = {174823}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg1607}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg1607}, day = {01}, doi = {10.1038/nrg1607}, issn = {1471-0056}, journal = {Nat Rev Genet}, keywords = {crohn-disease, ibd}, month = {May}, number = {5}, pages = {376--388}, posted-at = {2009-09-07 12:49:04}, priority = {5}, publisher = {Nature Publishing Group}, title = {Genetics of Crohn disease, an archetypal inflammatory barrier disease}, url = {http://dx.doi.org/10.1038/nrg1607}, volume = {6}, year = {2005} }

TY - JOUR ID - Schreiber2005 L3 - citeulike-article-id:174823 N2 - Chronic inflammatory disorders such as Crohn disease, atopic eczema, asthma and psoriasis are triggered by hitherto unknown environmental factors that function on the background of some polygenic susceptibility. Recent technological advances have allowed us to unravel the genetic aetiology of these and other complex diseases. Using Crohn disease as an example, we show how the discovery of susceptibility genes furthers our understanding of the underlying disease mechanisms and how it will, ultimately, give rise to new therapeutic developments. The long-term goal of such endeavours is to develop targeted prophylactic strategies. These will probably target the molecular interaction on the mucosal surface between the products of the genome and the microbial metagenome of a patient. IS - 5 JF - Nat Rev Genet SN - 1471-0056 EP - 388 TI - Genetics of Crohn disease, an archetypal inflammatory barrier disease PB - Nature Publishing Group VL - 6 SP - 376 KW - crohn-disease KW - ibd AU - Schreiber, Stefan AU - Rosenstiel, Philip AU - Albrecht, Mario AU - Hampe, Jochen AU - Krawczak, Michael PY - 2005/05/01/ UR - http://dx.doi.org/10.1038/nrg1607 ER -