How much do we have to pay for how many interim analyses? Export

@article{Koch2005, abstract = {From a methodological point of view, an enormous flexibility has been achieved with respect to the timing of interim analyses and the type I error alpha to be spend. Actual plans to spend alpha, however, are too often guided by the consideration of preserving as much alpha as possible for the final analysis. Practical consequences of spending tiny portions of alpha in many interim analyses are too often not appropriately acknowledged.}, author = {Koch, Armin}, citeulike-article-id = {3461343}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cct.2004.11.018}, doi = {10.1016/j.cct.2004.11.018}, journal = {Contemporary Clinical Trials}, keywords = {alpha-spending, analyses, clinical, file-import-08-10-29, interim, trials}, pages = {113--116}, posted-at = {2008-10-29 15:35:16}, priority = {0}, title = {How much do we have to pay for how many interim analyses?}, url = {http://dx.doi.org/10.1016/j.cct.2004.11.018}, volume = {26}, year = {2005} }

TY - JOUR ID - Koch2005 L3 - citeulike-article-id:3461343 N2 - From a methodological point of view, an enormous flexibility has been achieved with respect to the timing of interim analyses and the type I error alpha to be spend. Actual plans to spend alpha, however, are too often guided by the consideration of preserving as much alpha as possible for the final analysis. Practical consequences of spending tiny portions of alpha in many interim analyses are too often not appropriately acknowledged. JF - Contemporary Clinical Trials EP - 116 TI - How much do we have to pay for how many interim analyses? VL - 26 SP - 113 KW - alpha-spending KW - analyses KW - clinical KW - file-import-08-10-29 KW - interim KW - trials AU - Koch, Armin PY - 2005/// UR - http://dx.doi.org/10.1016/j.cct.2004.11.018 ER -