Increased Risk of Childhood Asthma From Antibiotic Use in Early Life Export

@article{Kozyrskyj2007, abstract = {Background: To address the major methodological issues of reverse causation and selection bias in epidemiologic studies of antibiotic use in early life and the development of asthma, we undertook a cohort study of this association in a complete population of children. Methods: Using the health-care and prescription databases of Manitoba, Canada, this longitudinal study assessed the association between antibiotic prescription use during the first year of life and asthma at age 7 years in a 1995 birth cohort of 13,116 children. Results: Independent of well-known asthma risk factors, asthma was significantly more likely to develop in children who had received antibiotics in the first year of life at age 7 years. The association with asthma was observed for antibiotic use in non-respiratory tract infections (adjusted odds ratio [OR], 1.86; 95\% confidence interval [CI], 1.02 to 3.37). The risk of asthma was highest in children receiving more than four courses of antibiotics (adjusted OR, 1.46; 95\% CI, 1.14 to 1.88), especially among rural children, and in the absence of maternal asthma or a dog in the birth year. Broad-spectrum (BS) cephalosporin use was more common in these subpopulations of children. Conclusions: Antibiotic use in early life was associated with the development of childhood asthma, a risk that may be reduced by avoiding the use of BS cephalosporins.}, author = {Kozyrskyj, Anita L. and Ernst, Pierre and Becker, Allan B.}, citeulike-article-id = {3461351}, citeulike-linkout-0 = {http://dx.doi.org/10.1378/chest.06-3008}, doi = {10.1378/chest.06-3008}, journal = {Chest}, keywords = {agents, antibacterial, asthma, child, file-import-08-10-29, infant}, pages = {1753--1759}, posted-at = {2008-10-29 15:35:16}, priority = {0}, title = {Increased Risk of Childhood Asthma From Antibiotic Use in Early Life}, url = {http://dx.doi.org/10.1378/chest.06-3008}, volume = {131}, year = {2007} }

TY - JOUR ID - Kozyrskyj2007 L3 - citeulike-article-id:3461351 N2 - Background: To address the major methodological issues of reverse causation and selection bias in epidemiologic studies of antibiotic use in early life and the development of asthma, we undertook a cohort study of this association in a complete population of children. Methods: Using the health-care and prescription databases of Manitoba, Canada, this longitudinal study assessed the association between antibiotic prescription use during the first year of life and asthma at age 7 years in a 1995 birth cohort of 13,116 children. Results: Independent of well-known asthma risk factors, asthma was significantly more likely to develop in children who had received antibiotics in the first year of life at age 7 years. The association with asthma was observed for antibiotic use in non-respiratory tract infections (adjusted odds ratio [OR], 1.86; 95% confidence interval [CI], 1.02 to 3.37). The risk of asthma was highest in children receiving more than four courses of antibiotics (adjusted OR, 1.46; 95% CI, 1.14 to 1.88), especially among rural children, and in the absence of maternal asthma or a dog in the birth year. Broad-spectrum (BS) cephalosporin use was more common in these subpopulations of children. Conclusions: Antibiotic use in early life was associated with the development of childhood asthma, a risk that may be reduced by avoiding the use of BS cephalosporins. JF - Chest EP - 1759 TI - Increased Risk of Childhood Asthma From Antibiotic Use in Early Life VL - 131 SP - 1753 KW - agents KW - antibacterial KW - asthma KW - child KW - file-import-08-10-29 KW - infant AU - Kozyrskyj, Anita AU - Ernst, Pierre AU - Becker, Allan PY - 2007/// UR - http://dx.doi.org/10.1378/chest.06-3008 ER -