The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation Export

@article{citeulike:6071727, abstract = {Abstract The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.}, author = {Park, Hyun H. and Lo, Yu C. and Lin, Su C. and Wang, Liwei and Yang, Jin K. and Wu, Hao}, citeulike-article-id = {6071727}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.immunol.25.022106.141656}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.immunol.25.022106.141656}, doi = {10.1146/annurev.immunol.25.022106.141656}, journal = {Annual Review of Immunology}, number = {1}, pages = {561--586}, posted-at = {2009-11-04 22:51:39}, priority = {2}, title = {The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation}, url = {http://dx.doi.org/10.1146/annurev.immunol.25.022106.141656}, volume = {25}, year = {2007} }

TY - JOUR ID - citeulike:6071727 L3 - citeulike-article-id:6071727 N2 - Abstract The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains. IS - 1 JF - Annual Review of Immunology EP - 586 TI - The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation VL - 25 SP - 561 AU - Park, Hyun AU - Lo, Yu AU - Lin, Su AU - Wang, Liwei AU - Yang, Jin AU - Wu, Hao PY - 2007/// UR - http://dx.doi.org/10.1146/annurev.immunol.25.022106.141656 ER -