Capecitabine Plus Erlotinib in Gemcitabine-Refractory Advanced Pancreatic Cancer Export

@article{citeulike:2294100, abstract = {PurposeThe addition of either capecitabine or erlotinib to gemcitabine in the first-line treatment of advanced pancreatic cancer is associated with modest improvements in overall survival. We evaluated an oral regimen of capecitabine and erlotinib in patients with advanced pancreatic cancer who had experienced treatment failure with standard first-line therapy with gemcitabine. Patients and MethodsThirty patients with gemcitabine-refractory metastatic pancreatic cancer were treated with capecitabine, administered at a dose of 1,000 mg/m2 twice daily for 2 weeks, followed by a 1-week break. All patients also received erlotinib 150 mg daily. Patients were observed for evidence of response, toxicity, and survival. EGFR mutational status was assessed in available tumor blocks. ResultsTreatment with capecitabine and erlotinib in gemcitabine-refractory patients was associated with an overall objective radiologic response rate of 10\% and a median survival duration of 6.5 months. In addition, 17\% of the treated patients experienced decreases in tumor marker (CA 19-9) levels of more than 50\% from baseline. Common toxicities included diarrhea, skin rash, fatigue, and hand-foot syndrome. EGFR mutations were detected in two of five available tumors; no association between treatment response and EGFR mutational status was evident. ConclusionThe combination of capecitabine and erlotinib is active in patients with gemcitabine-refractory pancreatic cancer. This regimen may represent an acceptable treatment option in patients who experience treatment failure with standard first-line therapy with gemcitabine or for whom gemcitabine may not be an appropriate first-line treatment option. 10.1200/JCO.2007.11.8521}, author = {Kulke, Matthew H. and Blaszkowsky, Lawrence S. and Ryan, David P. and Clark, Jeffrey W. and Meyerhardt, Jeffrey A. and Zhu, Andrew X. and Enzinger, Peter C. and Kwak, Eunice L. and Muzikansky, Alona and Lawrence, Colleen and Fuchs, Charles S.}, citeulike-article-id = {2294100}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2007.11.8521}, citeulike-linkout-1 = {http://jco.ascopubs.org/content/25/30/4787.abstract}, citeulike-linkout-2 = {http://jco.ascopubs.org/content/25/30/4787.full.pdf}, citeulike-linkout-3 = {http://jco.ascopubs.org/cgi/content/abstract/25/30/4787}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17947726}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17947726}, day = {20}, doi = {10.1200/JCO.2007.11.8521}, journal = {J Clin Oncol}, keywords = {cancer, clinical, oncology, pancreatic}, month = {October}, number = {30}, pages = {4787--4792}, posted-at = {2009-10-21 00:11:24}, priority = {2}, title = {Capecitabine Plus Erlotinib in Gemcitabine-Refractory Advanced Pancreatic Cancer}, url = {http://dx.doi.org/10.1200/JCO.2007.11.8521}, volume = {25}, year = {2007} }

TY - JOUR ID - citeulike:2294100 L3 - citeulike-article-id:2294100 N2 - PurposeThe addition of either capecitabine or erlotinib to gemcitabine in the first-line treatment of advanced pancreatic cancer is associated with modest improvements in overall survival. We evaluated an oral regimen of capecitabine and erlotinib in patients with advanced pancreatic cancer who had experienced treatment failure with standard first-line therapy with gemcitabine. Patients and MethodsThirty patients with gemcitabine-refractory metastatic pancreatic cancer were treated with capecitabine, administered at a dose of 1,000 mg/m2 twice daily for 2 weeks, followed by a 1-week break. All patients also received erlotinib 150 mg daily. Patients were observed for evidence of response, toxicity, and survival. EGFR mutational status was assessed in available tumor blocks. ResultsTreatment with capecitabine and erlotinib in gemcitabine-refractory patients was associated with an overall objective radiologic response rate of 10% and a median survival duration of 6.5 months. In addition, 17% of the treated patients experienced decreases in tumor marker (CA 19-9) levels of more than 50% from baseline. Common toxicities included diarrhea, skin rash, fatigue, and hand-foot syndrome. EGFR mutations were detected in two of five available tumors; no association between treatment response and EGFR mutational status was evident. ConclusionThe combination of capecitabine and erlotinib is active in patients with gemcitabine-refractory pancreatic cancer. This regimen may represent an acceptable treatment option in patients who experience treatment failure with standard first-line therapy with gemcitabine or for whom gemcitabine may not be an appropriate first-line treatment option. 10.1200/JCO.2007.11.8521 IS - 30 JF - J Clin Oncol EP - 4792 TI - Capecitabine Plus Erlotinib in Gemcitabine-Refractory Advanced Pancreatic Cancer VL - 25 SP - 4787 KW - cancer KW - clinical KW - oncology KW - pancreatic AU - Kulke, Matthew AU - Blaszkowsky, Lawrence AU - Ryan, David AU - Clark, Jeffrey AU - Meyerhardt, Jeffrey AU - Zhu, Andrew AU - Enzinger, Peter AU - Kwak, Eunice AU - Muzikansky, Alona AU - Lawrence, Colleen AU - Fuchs, Charles PY - 2007/10/20/ UR - http://dx.doi.org/10.1200/JCO.2007.11.8521 ER -