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Org. Lett. In Organic Letters, Vol. 13, No. 2. (8 December 2010), pp. 280-283, doi:10.1021/ol1026848 Key: citeulike:11865524
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A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
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