Bmp4 and Morphological Variation of Beaks in Darwin's Finches Export

@article{citeulike:1414471, abstract = {Darwin's finches are a classic example of species diversification by natural selection. Their impressive variation in beak morphology is associated with the exploitation of a variety of ecological niches, but its developmental basis is unknown. We performed a comparative analysis of expression patterns of various growth factors in species comprising the genus Geospiza. We found that expression of Bmp4 in the mesenchyme of the upper beaks strongly correlated with deep and broad beak morphology. When misexpressed in chicken embryos, Bmp4 caused morphological transformations paralleling the beak morphology of the large ground finch G. magnirostris. 10.1126/science.1098095}, author = {Abzhanov, Arhat and Protas, Meredith and Grant, Rosemary B. and Grant, Peter R. and Tabin, Clifford J.}, citeulike-article-id = {1414471}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1098095}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/305/5689/1462}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15353802}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15353802}, day = {3}, doi = {10.1126/science.1098095}, journal = {Science}, keywords = {bmp4, darwin, evolution, finch, selection}, month = {September}, number = {5689}, pages = {1462--1465}, posted-at = {2008-07-01 16:46:46}, priority = {2}, title = {Bmp4 and Morphological Variation of Beaks in Darwin's Finches}, url = {http://dx.doi.org/10.1126/science.1098095}, volume = {305}, year = {2004} }

TY - JOUR ID - citeulike:1414471 L3 - citeulike-article-id:1414471 N2 - Darwin's finches are a classic example of species diversification by natural selection. Their impressive variation in beak morphology is associated with the exploitation of a variety of ecological niches, but its developmental basis is unknown. We performed a comparative analysis of expression patterns of various growth factors in species comprising the genus Geospiza. We found that expression of Bmp4 in the mesenchyme of the upper beaks strongly correlated with deep and broad beak morphology. When misexpressed in chicken embryos, Bmp4 caused morphological transformations paralleling the beak morphology of the large ground finch G. magnirostris. 10.1126/science.1098095 IS - 5689 JF - Science EP - 1465 TI - Bmp4 and Morphological Variation of Beaks in Darwin's Finches VL - 305 SP - 1462 KW - bmp4 KW - darwin KW - evolution KW - finch KW - selection AU - Abzhanov, Arhat AU - Protas, Meredith AU - Grant, Rosemary AU - Grant, Peter AU - Tabin, Clifford PY - 2004/09/03/ UR - http://dx.doi.org/10.1126/science.1098095 ER -