Association of a Serotonin Transporter Polymorphism (5-HTTLPR) With Depression, Perceived Stress, and Norepinephrine in Patients With Coronary Disease: The Heart and Soul Study. Export

@article{citeulike:1613190, abstract = {OBJECTIVE: The short allele of a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to interact with stressful life events to predict depression in otherwise healthy individuals. Whether the short allele increases risk for depression associated with the stress of a chronic illness has not been established. METHOD: In a cross-sectional genetic association study, the authors examined the association of 5-HTTLPR with current depression (measured by the Computerized Diagnostic Interview Schedule), perceived stress (measured by the Perceived Stress Scale), and 24-hour urinary norepinephrine excretion in 557 outpatients with chronic coronary disease. RESULTS: Among individuals carrying an s allele, 25\% (97 of 383) had current depression, compared with 17\% (29 of 174) of l/l homozygotes. The unadjusted odds ratio was 1.6, with a 95\% confidence interval (CI) of 1.0-2.6; the age- and gender-adjusted odds ratio was also 1.6 (95\% CI=1.0-2.5). Participants carrying an s allele had a higher mean score for perceived stress than l/l homozygotes (5.4 versus 4.7) and a higher rate of moderate or high perceived stress (adjusted odds ratio=1.6, 95\% CI=1.1-2.3). Mean 24-hour norepinephrine excretion was higher in s allele carriers (55.6 versus 50.2 mg/day), who were more likely to have norepinephrine values in the highest quartile (adjusted odds ratio=1.7, 95\% CI=1.0-3.0). CONCLUSIONS: Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion. These factors may contribute to worse cardiovascular outcomes in these patients.}, address = {Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. otte@uke.uni-hamburg.de.}, author = {Otte, C. and McCaffery, J. and Ali, S. and Whooley, M. A.}, citeulike-article-id = {1613190}, citeulike-linkout-0 = {http://dx.doi.org/10.1176/appi.ajp.2007.06101617}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17728423}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17728423}, doi = {10.1176/appi.ajp.2007.06101617}, issn = {0002-953X}, journal = {Am J Psychiatry}, keywords = {anti\_depressant, cardiology, clinical\_trial, genetics, major\_depression}, month = {September}, number = {9}, pages = {1379--1384}, posted-at = {2007-09-01 23:09:19}, priority = {4}, title = {Association of a Serotonin Transporter Polymorphism (5-HTTLPR) With Depression, Perceived Stress, and Norepinephrine in Patients With Coronary Disease: The Heart and Soul Study.}, url = {http://dx.doi.org/10.1176/appi.ajp.2007.06101617}, volume = {164}, year = {2007} }

TY - JOUR ID - citeulike:1613190 L3 - citeulike-article-id:1613190 N2 - OBJECTIVE: The short allele of a functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been shown to interact with stressful life events to predict depression in otherwise healthy individuals. Whether the short allele increases risk for depression associated with the stress of a chronic illness has not been established. METHOD: In a cross-sectional genetic association study, the authors examined the association of 5-HTTLPR with current depression (measured by the Computerized Diagnostic Interview Schedule), perceived stress (measured by the Perceived Stress Scale), and 24-hour urinary norepinephrine excretion in 557 outpatients with chronic coronary disease. RESULTS: Among individuals carrying an s allele, 25% (97 of 383) had current depression, compared with 17% (29 of 174) of l/l homozygotes. The unadjusted odds ratio was 1.6, with a 95% confidence interval (CI) of 1.0-2.6; the age- and gender-adjusted odds ratio was also 1.6 (95% CI=1.0-2.5). Participants carrying an s allele had a higher mean score for perceived stress than l/l homozygotes (5.4 versus 4.7) and a higher rate of moderate or high perceived stress (adjusted odds ratio=1.6, 95% CI=1.1-2.3). Mean 24-hour norepinephrine excretion was higher in s allele carriers (55.6 versus 50.2 mg/day), who were more likely to have norepinephrine values in the highest quartile (adjusted odds ratio=1.7, 95% CI=1.0-3.0). CONCLUSIONS: Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion. These factors may contribute to worse cardiovascular outcomes in these patients. IS - 9 JF - Am J Psychiatry SN - 0002-953X AD - Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. otte@uke.uni-hamburg.de. EP - 1384 TI - Association of a Serotonin Transporter Polymorphism (5-HTTLPR) With Depression, Perceived Stress, and Norepinephrine in Patients With Coronary Disease: The Heart and Soul Study. VL - 164 SP - 1379 KW - anti_depressant KW - cardiology KW - clinical_trial KW - genetics KW - major_depression AU - Otte, C AU - McCaffery, J AU - Ali, S AU - Whooley, MA PY - 2007/09// UR - http://dx.doi.org/10.1176/appi.ajp.2007.06101617 ER -