Neurobiology of aggression and violence.

@article{citeulike:2708123, abstract = {Acts of violence account for an estimated 1.43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances. In some individuals, repetitive acts of aggression are grounded in an underlying neurobiological susceptibility that is just beginning to be understood. The failure of "top-down" control systems in the prefrontal cortex to modulate aggressive acts that are triggered by anger provoking stimuli appears to play an important role. An imbalance between prefrontal regulatory influences and hyper-responsivity of the amygdala and other limbic regions involved in affective evaluation are implicated. Insufficient serotonergic facilitation of "top-down" control, excessive catecholaminergic stimulation, and subcortical imbalances of glutamatergic/gabaminergic systems as well as pathology in neuropeptide systems involved in the regulation of affiliative behavior may contribute to abnormalities in this circuitry. Thus, pharmacological interventions such as mood stabilizers, which dampen limbic irritability, or selective serotonin reuptake inhibitors (SSRIs), which may enhance "top-down" control, as well as psychosocial interventions to develop alternative coping skills and reinforce reflective delays may be therapeutic.}, address = {Department of Psychiatry (OOMH), 130 West Kingsbridge Rd., Bronx, NY 10468. Larry.Siever@va.gov.}, author = {Siever, L. J. }, citeulike-article-id = {2708123}, doi = {10.1176/appi.ajp.2008.07111774}, issn = {0002-953X}, journal = {The American journal of psychiatry}, keywords = {review, social\_study, theory}, month = {April}, number = {4}, pages = {429--442}, posted-at = {2008-04-23 17:28:44}, priority = {0}, title = {Neurobiology of aggression and violence.}, url = {http://dx.doi.org/10.1176/appi.ajp.2008.07111774}, volume = {165}, year = {2008} }

TY - JOUR ID - citeulike:2708123 L3 - citeulike-article-id:2708123 TI - Neurobiology of aggression and violence. JF - The American journal of psychiatry VL - 165 IS - 4 SP - 429 EP - 442 AD - Department of Psychiatry (OOMH), 130 West Kingsbridge Rd., Bronx, NY 10468. Larry.Siever@va.gov. SN - 0002-953X N2 - Acts of violence account for an estimated 1.43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances. In some individuals, repetitive acts of aggression are grounded in an underlying neurobiological susceptibility that is just beginning to be understood. The failure of "top-down" control systems in the prefrontal cortex to modulate aggressive acts that are triggered by anger provoking stimuli appears to play an important role. An imbalance between prefrontal regulatory influences and hyper-responsivity of the amygdala and other limbic regions involved in affective evaluation are implicated. Insufficient serotonergic facilitation of "top-down" control, excessive catecholaminergic stimulation, and subcortical imbalances of glutamatergic/gabaminergic systems as well as pathology in neuropeptide systems involved in the regulation of affiliative behavior may contribute to abnormalities in this circuitry. Thus, pharmacological interventions such as mood stabilizers, which dampen limbic irritability, or selective serotonin reuptake inhibitors (SSRIs), which may enhance "top-down" control, as well as psychosocial interventions to develop alternative coping skills and reinforce reflective delays may be therapeutic. KW - review KW - social_study KW - theory AU - Siever, LJ PY - 2008/04// UR - http://dx.doi.org/10.1176/appi.ajp.2008.07111774 ER -