Synaptic plasticity and addiction. Export

@article{citeulike:1794730, abstract = {Addiction is caused, in part, by powerful and long-lasting memories of the drug experience. Relapse caused by exposure to cues associated with the drug experience is a major clinical problem that contributes to the persistence of addiction. Here we present the accumulated evidence that drugs of abuse can hijack synaptic plasticity mechanisms in key brain circuits, most importantly in the mesolimbic dopamine system, which is central to reward processing in the brain. Reversing or preventing these drug-induced synaptic modifications may prove beneficial in the treatment of one of society's most intractable health problems.}, author = {Kauer, Julie A. and Malenka, Robert C.}, citeulike-article-id = {1794730}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrn2234}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrn2234}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17948030}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17948030}, doi = {10.1038/nrn2234}, issn = {1471-0048}, journal = {Nature reviews. Neuroscience}, keywords = {addiction, camkii, camp, dopamine, glutamate, learning, memory, plasticity}, month = {November}, number = {11}, pages = {844--858}, posted-at = {2008-01-23 10:23:15}, priority = {0}, publisher = {Nature Publishing Group}, title = {Synaptic plasticity and addiction.}, url = {http://dx.doi.org/10.1038/nrn2234}, volume = {8}, year = {2007} }

TY - JOUR ID - citeulike:1794730 L3 - citeulike-article-id:1794730 N2 - Addiction is caused, in part, by powerful and long-lasting memories of the drug experience. Relapse caused by exposure to cues associated with the drug experience is a major clinical problem that contributes to the persistence of addiction. Here we present the accumulated evidence that drugs of abuse can hijack synaptic plasticity mechanisms in key brain circuits, most importantly in the mesolimbic dopamine system, which is central to reward processing in the brain. Reversing or preventing these drug-induced synaptic modifications may prove beneficial in the treatment of one of society's most intractable health problems. IS - 11 JF - Nature reviews. Neuroscience SN - 1471-0048 EP - 858 TI - Synaptic plasticity and addiction. PB - Nature Publishing Group VL - 8 SP - 844 KW - addiction KW - camkii KW - camp KW - dopamine KW - glutamate KW - learning KW - memory KW - plasticity AU - Kauer, Julie AU - Malenka, Robert PY - 2007/11// UR - http://dx.doi.org/10.1038/nrn2234 ER -