Haplotype blocks and linkage disequilibrium in the human genome. Export

@article{citeulike:2973010, abstract = {There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.}, address = {Department of Human Genetics, The University of Chicago, 920 East 58th Street, CLSC 507, Chicago, Illinois 60637, USA. jwall@genetics.bsd.uchicago.edu}, author = {Wall, J. D. and Pritchard, J. K.}, citeulike-article-id = {2973010}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg1123}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg1123}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12897771}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12897771}, doi = {10.1038/nrg1123}, issn = {1471-0056}, journal = {Nature reviews. Genetics}, keywords = {genetics, genomics, ld}, month = {August}, number = {8}, pages = {587--597}, posted-at = {2008-09-22 12:53:26}, priority = {3}, title = {Haplotype blocks and linkage disequilibrium in the human genome.}, url = {http://dx.doi.org/10.1038/nrg1123}, volume = {4}, year = {2003} }

TY - JOUR ID - citeulike:2973010 L3 - citeulike-article-id:2973010 N2 - There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations. IS - 8 JF - Nature reviews. Genetics SN - 1471-0056 AD - Department of Human Genetics, The University of Chicago, 920 East 58th Street, CLSC 507, Chicago, Illinois 60637, USA. jwall@genetics.bsd.uchicago.edu EP - 597 TI - Haplotype blocks and linkage disequilibrium in the human genome. VL - 4 SP - 587 KW - genetics KW - genomics KW - ld AU - Wall, JD AU - Pritchard, JK PY - 2003/08// UR - http://dx.doi.org/10.1038/nrg1123 ER -