Common polygenic variation contributes to risk of schizophrenia and bipolar disorder Export

@article{citeulike:5135705, abstract = {Schizophrenia is a severe mental disorder with a lifetime risk of about 1\%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80\%1, 2. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.}, author = {Consortium, International S.}, citeulike-article-id = {5135705}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08185}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08185}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19571811}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19571811}, day = {01}, doi = {10.1038/nature08185}, issn = {0028-0836}, journal = {Nature}, keywords = {cardiff, genomics, methods, polygenic\_score, schizo}, month = {July}, number = {7256}, pages = {748--752}, posted-at = {2009-10-11 11:57:37}, priority = {0}, publisher = {Nature Publishing Group}, title = {Common polygenic variation contributes to risk of schizophrenia and bipolar disorder}, url = {http://dx.doi.org/10.1038/nature08185}, volume = {460}, year = {2009} }

TY - JOUR ID - citeulike:5135705 L3 - citeulike-article-id:5135705 N2 - Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%1, 2. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases. IS - 7256 JF - Nature SN - 0028-0836 EP - 752 TI - Common polygenic variation contributes to risk of schizophrenia and bipolar disorder PB - Nature Publishing Group VL - 460 SP - 748 KW - cardiff KW - genomics KW - methods KW - polygenic_score KW - schizo AU - Consortium, International PY - 2009/07/01/ UR - http://dx.doi.org/10.1038/nature08185 ER -