The genetics of Parkinson's syndromes: a critical review. Export

@article{citeulike:5372789, abstract = {Genetic analysis has identified many loci designated as PARK loci (OMIM \#168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.}, author = {Hardy, John and Lewis, Patrick and Revesz, Tamas and Lees, Andrew and Paisan-Ruiz, Coro}, citeulike-article-id = {5372789}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.gde.2009.03.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0959437X09000550}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19419854}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19419854}, doi = {10.1016/j.gde.2009.03.008}, issn = {1879-0380}, journal = {Current opinion in genetics \& development}, keywords = {genetics, parkinsons, review}, month = {June}, number = {3}, pages = {254--265}, posted-at = {2009-10-06 18:09:44}, priority = {0}, title = {The genetics of Parkinson's syndromes: a critical review.}, url = {http://dx.doi.org/10.1016/j.gde.2009.03.008}, volume = {19}, year = {2009} }

TY - JOUR ID - citeulike:5372789 L3 - citeulike-article-id:5372789 N2 - Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C. IS - 3 JF - Current opinion in genetics & development SN - 1879-0380 EP - 265 TI - The genetics of Parkinson's syndromes: a critical review. VL - 19 SP - 254 KW - genetics KW - parkinsons KW - review AU - Hardy, John AU - Lewis, Patrick AU - Revesz, Tamas AU - Lees, Andrew AU - Paisan-Ruiz, Coro PY - 2009/06// UR - http://dx.doi.org/10.1016/j.gde.2009.03.008 ER -