Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Export

@article{citeulike:5850169, abstract = {Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95\% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008.}, author = {Ross, Owen A. and Wu, Yih-Ru R. and Lee, Mei-Ching C. and Funayama, Manabu and Chen, Meng-Ling L. and Soto, Alexandra I. and Mata, Ignacio F. and Lee-Chen, Guey-Jen J. and Chen, Chiung Mei M. and Tang, Michelle and Zhao, Yi and Hattori, Nobutaka and Farrer, Matthew J. and Tan, Eng-King K. and Wu, Ruey-Meei M.}, citeulike-article-id = {5850169}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ana.21405}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18412265}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18412265}, doi = {10.1002/ana.21405}, issn = {1531-8249}, journal = {Annals of neurology}, keywords = {genetics, lrrk2, parkinsons, snp}, month = {July}, number = {1}, pages = {88--92}, posted-at = {2009-09-29 17:32:15}, priority = {0}, title = {Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.}, url = {http://dx.doi.org/10.1002/ana.21405}, volume = {64}, year = {2008} }

TY - JOUR ID - citeulike:5850169 L3 - citeulike-article-id:5850169 N2 - Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008. IS - 1 JF - Annals of neurology SN - 1531-8249 EP - 92 TI - Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. VL - 64 SP - 88 KW - genetics KW - lrrk2 KW - parkinsons KW - snp AU - Ross, Owen AU - Wu, Yih-Ru AU - Lee, Mei-Ching AU - Funayama, Manabu AU - Chen, Meng-Ling AU - Soto, Alexandra AU - Mata, Ignacio AU - Lee-Chen, Guey-Jen AU - Chen, Chiung Mei AU - Tang, Michelle AU - Zhao, Yi AU - Hattori, Nobutaka AU - Farrer, Matthew AU - Tan, Eng-King AU - Wu, Ruey-Meei PY - 2008/07// UR - http://dx.doi.org/10.1002/ana.21405 ER -