pslee's library 36 articles Export

	From fragment to clinical candidate—a historical perspective [My Copy] Drug Discovery Today, Vol. 14, No. 13-14. (07 July 2009), pp. 668-675. by Gianni Chessari, Andrew J. Woodhead posted to astex cdk2 factor fbdd ppar xa by pslee on 2009-05-08 22:41:51 as along with 1 group Fragment Based Drug Discovery
	Transforming fragments into candidates: small becomes big in medicinal chemistry [My Copy] Drug Discovery Today, Vol. 14, No. 13-14. (31 July 2009), pp. 630-646. by Gerdien E. de Kloe, David Bailey, Rob Leurs, Iwan J. P. de Esch posted to fbdd by pslee on 2009-04-03 17:32:58 as along with 1 person and 1 group sschurer Fragment Based Drug Discovery
	Molecular docking and ligand specificity in fragment-based inhibitor discovery [My Copy] Nat Chem Biol, Vol. 5, No. 5. (22 May 2009), pp. 358-364. by Yu Chen, Brian K. Shoichet posted to docking fbdd shoichet ucsf by pslee on 2009-03-25 22:32:22 as along with 3 people and 1 group Faben reyez ubcg08l Fragment Based Drug Discovery
	Design of compound libraries for fragment screening [My Copy] Journal of Computer-Aided Molecular Design by Niklas Blomberg, David Cosgrove, Peter Kenny, Karin Kolmodin posted to astrazeneca fbdd by pslee on 2009-03-24 18:13:05 as along with 1 person and 1 group JALumley Fragment Based Drug Discovery
	Evidence for C&bond;Cl/C&bond;Brsdotsdotsdotpi Interactions as an Important Contribution to Protein-Ligand Binding Affinity [My Copy] Angewandte Chemie International Edition, Vol. 9999, No. 9999. (2009), NA. by Hans Matter, Marc Nazaré, Stefan Güssregen, et al.David W. Will, Herman Schreuder, Armin Bauer, Matthias Urmann, Kurt Ritter, Michael Wagner, Volkmar Wehner posted to halogen sanofi-aventis sbdd by pslee on 2009-03-24 17:58:17 as
	The influence of lead discovery strategies on the properties of drug candidates [My Copy] Nat Rev Drug Discov, Vol. 8, No. 3. (March 2009), pp. 203-212. by Gyorgy M. Keseru, Gergely M. Makara posted to drug lipophilicity properties by pslee on 2009-03-05 22:25:42 as along with 2 people and 1 group higueruelo cesar McCammon
	Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization [My Copy] (01 February 2008) by Edward Kerns, Li Di posted to adme by pslee on 2009-02-12 17:45:08 as along with 1 person reyez
	The role of molecular size in ligand efficiency [My Copy] Bioorganic & Medicinal Chemistry Letters, Vol. 17, No. 15. (01 August 2007), pp. 4258-4261. by C. Reynolds, S. Bembenek, B. Tounge posted to fbdd janj le by pslee on 2009-01-29 20:40:02 as along with 1 group Fragment Based Drug Discovery
	Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors. [My Copy] Drug discovery today, Vol. 14, No. 5-6. (21 March 2009), pp. 291-297. by Irini Akritopoulou-Zanze, Philip J. Hajduk posted to abbott kinase by pslee on 2009-01-26 17:44:47 as along with 3 people guhjy Yanno sschurer
	The maximal affinity of ligands. [My Copy] Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 18. (31 August 1999), pp. 9997-10002. by I. D. Kuntz, K. Chen, K. A. Sharp, P. A. Kollman posted to affinity kuntz ligand ucsf by pslee on 2009-01-19 18:15:51 as along with 6 people higueruelo ubcg08l bicko BragilMassoud alexg superpyrin
	Two 'Golden Ratio' indices in fragment-based drug discovery. [My Copy] Drug discovery today, Vol. 14, No. 5-6. (10 March 2009), pp. 321-328. by Masaya Orita, Kazuki Ohno, Tatsuya Niimi posted to astellas fbdd by pslee on 2009-01-19 18:12:48 as along with 1 person and 1 group ubcg08l Fragment Based Drug Discovery
	Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery [My Copy] Journal of Chemical Information and Computer Sciences, Vol. 41, No. 3. (1 May 2001), pp. 856-864. by Michael M. Hann, Andrew R. Leach, Gavin Harper posted to fbdd by pslee on 2009-01-15 21:41:09 as along with 3 people and 1 group JALumley ubcg08l middledomain Fragment Based Drug Discovery
	Fragment-Based Drug Discovery: What has it Achieved so Far? [My Copy] Curr. Topics in Med. Chem., Vol. 7 (2007), pp. 1544-1567. by Alexander A. Alex, Maria M. Flocco posted to fbdd pfizer by pslee on 2009-01-09 23:56:27 as along with 1 group Fragment Based Drug Discovery
	Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent [My Copy] Proceedings of the National Academy of Sciences, Vol. 106, No. 1. (6 January 2009), pp. 262-267. by Dean R. Artis, Jack J. Lin, Chao Zhang, et al.Weiru Wang, Upasana Mehra, Mylene Perreault, David Erbe, Heike I. Krupka, Bruce P. England, James Arnold, Alexander N. Plotnikov, Adhirai Marimuthu, Hoa Nguyen, Sarah Will, Maxime Signaevsky, John Kral, John Cantwell, Calvin Settachatgull, Douglas S. Yan, Daniel Fong, Angela Oh, Shenghua Shi, Patrick Womack, Benjamin Powell, Gaston Habets, Brian L. West, Kam Y. Zhang, Michael V. Milburn, George P. Vlasuk, Peter K. Hirth, Keith Nolop, Gideon Bollag, Prabha N. Ibrahim, James F. Tobin posted to fbdd plexxikon ppar by pslee on 2009-01-08 18:23:19 as
	Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors [My Copy] Science, Vol. 281, No. 5376. (24 July 1998), pp. 533-538. by Nathanael S. Gray, Lisa Wodicka, Andy-Mark W. Thunnissen, et al.Thea C. Norman, Soojin Kwon, Hernan F. Espinoza, David O. Morgan, Georjana Barnes, Sophie Leclerc, Laurent Meijer, Sung-Hou Kim, David J. Lockhart, Peter G. Schultz posted to cdk cdk2 by pslee on 2009-01-07 23:04:12 as
	Fragment-based Approaches in Drug Discovery (Methods and Principles in Medicinal Chemistry) [My Copy] (27 October 2006) posted to fbdd sgx x-ray by pslee on 2009-01-07 19:57:41 as along with 1 group Fragment Based Drug Discovery
	Features of selective kinase inhibitors. [My Copy] Chem Biol, Vol. 12, No. 6. (June 2005), pp. 621-637. by Z. A. Knight, K. M. Shokat posted to atp berkeley kinase selective ucsf by pslee on 2009-01-06 23:13:06 as along with 4 people Yanno anwazo pjasper seancutler
	The influence of drug-like concepts on decision-making in medicinal chemistry [My Copy] Nature Reviews Drug Discovery, Vol. 6, No. 11., pp. 881-890. by Paul D. Leeson, Brian Springthorpe posted to astrazeneca drug logp properties by pslee on 2009-01-06 23:10:48 as along with 2 people higueruelo nicklynch
	Energetic Preferences for α,β versus β,γ Unsaturation [My Copy] The Journal of Organic Chemistry, Vol. 69, No. 16. (2004), pp. 5448-5453. by Patrick S. Lee, Wu Du, Dale L. Boger, William L. Jorgensen posted to b3lyp dft torsional yale by pslee on 2009-01-06 22:57:34 as
	Small Molecule Conformational Preferences Derived from Crystal Structure Data. A Medicinal Chemistry Focused Analysis [My Copy] Journal of Chemical Information and Modeling, Vol. 48, No. 1. (1 January 2008), pp. 1-24. by Ken A. Brameld, Bernd Kuhn, Deborah C. Reuter, Martin Stahl posted to csd pdb roche x-ray by pslee on 2009-01-06 22:53:46 as along with 2 people dimka daevans
	Fragonomics: fragment-based drug discovery [My Copy] Current Opinion in Chemical Biology In Next-generation therapeutics, Vol. 9, No. 4. (August 2005), pp. 366-370. by Edward R. Zartler, Michael J. Shapiro posted to fbdd lilly nmr by pslee on 2009-01-06 22:24:19 as along with 1 person massivemayhem
	Deconstructing fragment-based inhibitor discovery. [My Copy] Nature chemical biology, Vol. 2, No. 12. (December 2006), pp. 720-723. by K. Babaoglu, B. K. Shoichet posted to fbdd by pslee on 2009-01-06 22:22:24 as along with 1 person massivemayhem
	Predicting druggable binding sites at the protein-protein interface. [My Copy] Drug discovery today (25 November 2008) by Jonathan C C. Fuller, Nicholas J J. Burgoyne, Richard M M. Jackson posted to ppi protein-protein by pslee on 2009-01-06 19:14:21 as along with 4 people flbarroso tbinbal sschurer higueruelo
	Ligand efficiency and fragment-based drug discovery. [My Copy] Drug discovery today, Vol. 14, No. 5-6. (30 March 2009), pp. 278-283. by Scott D. Bembenek, Brett A. Tounge, Charles H. Reynolds posted to fbdd jandj le by pslee on 2009-01-06 19:11:48 as along with 3 people higueruelo jerome sschurer
	Limitations and lessons in the use of X-ray structural information in drug design [My Copy] Drug Discovery Today, Vol. 13, No. 19-20. (October 2008), pp. 831-841. by A. Davis, S. Stgallay, G. Kleywegt posted to astrazeneca x-ray by pslee on 2009-01-06 19:09:49 as along with 4 people ramalldf tbinbal massivemayhem thanatos
	Fragment-based screening using X-ray crystallography and NMR spectroscopy [My Copy] Current Opinion in Chemical Biology, Vol. 11, No. 5. (October 2007), pp. 485-493. by H. Jhoti, A. Cleasby, M. Verdonk, G. Williams posted to astex methods nmr x-ray by pslee on 2009-01-06 18:25:16 as along with 2 people jwm massivemayhem
	Fragment-based lead discovery: leads by design [My Copy] Drug Discovery Today, Vol. 10, No. 14. (15 July 2005), pp. 987-992. by R. Carr, M. Congreve, C. Murray, D. Rees posted to astex fbdd by pslee on 2009-01-06 18:20:47 as along with 1 person and 1 group tbinbal Fragment Based Drug Discovery
	Library Design for Fragment Based Screening [My Copy] Current Topics in Medicinal Chemistry, Vol. 5, No. 8. (August 2005), pp. 751-762. by Ansgar Schuffenhauer, Simon Ruedisser, Andreas Marzinzik, Wolfgang Jahnke, Paul Selzer, Edgar Jacoby posted to fbdd methods nmr x-ray by pslee on 2009-01-06 18:14:54 as
	Fragment-based activity space: smaller is better [My Copy] Current Opinion in Chemical Biology, Vol. In Press, Corrected Proof by Thomas Hesterkamp, Mark Whittaker posted to evotec fbdd nmr by pslee on 2009-01-06 17:59:19 as along with 1 person jerome_ucsf_slb
	A decade of fragment-based drug design: strategic advances and lessons learned [My Copy] Nat Rev Drug Discov, Vol. 6, No. 3. (09 March 2007), pp. 211-219. by Philip J. Hajduk, Jonathan Greer posted to abbott fbdd by pslee on 2009-01-06 17:54:31 as along with 6 people and 1 group ubcg08l jerome dgruiz bicko massivemayhem jerome_ucsf_slb Fragment Based Drug Discovery
	Fragment-based drug discovery. [My Copy] J Med Chem, Vol. 47, No. 14. (1 July 2004), pp. 3463-3482. by D. A. Erlanson, R. S. McDowell, T. O'Brien posted to fbdd methods screening sunesis by pslee on 2009-01-06 16:12:33 as along with 2 people and 3 groups nachtalp sangeetha Fragment Based Drug Discovery Bioinformatics insilicodrug
	The fragment-approach: An update [My Copy] Drug Discovery Today: Technologies, Vol. 3, No. 4. (FebruaryApril 2006), pp. 425-431. by S. Bartoli, C. Fincham, D. Fattori posted to fbdd mass methods nmr spec x-ray by pslee on 2009-01-06 16:03:11 as along with 1 group Fragment Based Drug Discovery
	Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity† [My Copy] Journal of Medicinal Chemistry, Vol. 0, No. 0. (0000) by Steven Howard, Valerio Berdini, John A. Boulstridge, et al.Maria G. Carr, David M. Cross, Jayne Curry, Lindsay A. Devine, Theresa R. Early, Lynsey Fazal, Adrian L. Gill, Michelle Heathcote, Sarita Maman, Julia E. Matthews, Rachel L. Mcmenamin, Eva F. Navarro, Michael A. O’brien, Marc O’reilly, David C. Rees, Matthias Reule, Dominic Tisi, Glyn Williams, Mladen Vinković, Paul G. Wyatt posted to abl astex at9283 aurora fbdd jak2 by pslee on 2009-01-06 16:00:44 as
	Discovering novel ligands for macromolecules using X-ray crystallographic screening [My Copy] Nat Biotech, Vol. 18, No. 10. (October 2000), pp. 1105-1108. by Vicki L. Nienaber, Paul L. Richardson, Vered Klighofer, Jennifer J. Bouska, Vincent L. Giranda, Jonathan Greer posted to abbott fbdd x-ray by pslee on 2009-01-06 15:58:40 as along with 1 group Fragment Based Drug Discovery
	Recent Developments in Fragment-Based Drug Discovery [My Copy] Journal of Medicinal Chemistry, Vol. 51, No. 13. (1 July 2008), pp. 3661-3680. by Miles Congreve, Gianni Chessari, Dominic Tisi, Andrew J. Woodhead posted to astex fbdd le lle by pslee on 2009-01-06 15:53:09 as along with 5 people and 1 group hmk ubcg08l jerome higueruelo vaibhavdixit4 Fragment Based Drug Discovery
	Fragment-Based Lead Discovery Using X-ray Crystallography [My Copy] Journal of Medicinal Chemistry, Vol. 48, No. 2. (1 January 2005), pp. 403-413. by Michael J. Hartshorn, Christopher W. Murray, Anne Cleasby, Martyn Frederickson, Ian J. Tickle, Harren Jhoti posted to a astex cdk2 fbdd p38 ptp1b ribonuclease thrombin x-ray by pslee on 2009-01-06 15:48:25 as along with 2 people and 1 group ubcg08l dgruiz Fragment Based Drug Discovery

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astex	6
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pslee's library 36 articles Export

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