A Role for the CHC22 Clathrin Heavy-Chain Isoform in Human Glucose Metabolism Export

@article{citeulike:4680567, abstract = {Intracellular trafficking of the glucose transporter GLUT4 from storage compartments to the plasma membrane is triggered in muscle and fat during the body's response to insulin. Clathrin is involved in intracellular trafficking, and in humans, the clathrin heavy-chain isoform CHC22 is highly expressed in skeletal muscle. We found a role for CHC22 in the formation of insulin-responsive GLUT4 compartments in human muscle and adipocytes. CHC22 also associated with expanded GLUT4 compartments in muscle from type 2 diabetic patients. Tissue-specific introduction of CHC22 in mice, which have only a pseudogene for this protein, caused aberrant localization of GLUT4 transport pathway components in their muscle, as well as features of diabetes. Thus, CHC22-dependent membrane trafficking constitutes a species-restricted pathway in human muscle and fat with potential implications for type 2 diabetes. 10.1126/science.1171529}, author = {Vassilopoulos, Stephane and Esk, Christopher and Hoshino, Sachiko and Funke, Birgit H. and Chen, Chih-Ying and Plocik, Alex M. and Wright, Woodring E. and Kucherlapati, Raju and Brodsky, Frances M.}, citeulike-article-id = {4680567}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1171529}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5931/1192}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19478182}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19478182}, doi = {10.1126/science.1171529}, journal = {Science}, keywords = {cross-species, diabetes, glucose, man, metabolism, mouse}, month = {May}, number = {5931}, pages = {1192--1196}, posted-at = {2009-06-03 20:49:32}, priority = {2}, title = {A Role for the CHC22 Clathrin Heavy-Chain Isoform in Human Glucose Metabolism}, url = {http://dx.doi.org/10.1126/science.1171529}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4680567 L3 - citeulike-article-id:4680567 N2 - Intracellular trafficking of the glucose transporter GLUT4 from storage compartments to the plasma membrane is triggered in muscle and fat during the body's response to insulin. Clathrin is involved in intracellular trafficking, and in humans, the clathrin heavy-chain isoform CHC22 is highly expressed in skeletal muscle. We found a role for CHC22 in the formation of insulin-responsive GLUT4 compartments in human muscle and adipocytes. CHC22 also associated with expanded GLUT4 compartments in muscle from type 2 diabetic patients. Tissue-specific introduction of CHC22 in mice, which have only a pseudogene for this protein, caused aberrant localization of GLUT4 transport pathway components in their muscle, as well as features of diabetes. Thus, CHC22-dependent membrane trafficking constitutes a species-restricted pathway in human muscle and fat with potential implications for type 2 diabetes. 10.1126/science.1171529 IS - 5931 JF - Science EP - 1196 TI - A Role for the CHC22 Clathrin Heavy-Chain Isoform in Human Glucose Metabolism VL - 324 SP - 1192 KW - cross-species KW - diabetes KW - glucose KW - man KW - metabolism KW - mouse AU - Vassilopoulos, Stephane AU - Esk, Christopher AU - Hoshino, Sachiko AU - Funke, Birgit AU - Chen, Chih-Ying AU - Plocik, Alex AU - Wright, Woodring AU - Kucherlapati, Raju AU - Brodsky, Frances PY - 2009/05/29/ UR - http://dx.doi.org/10.1126/science.1171529 ER -