Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine Export

@article{citeulike:4646488, abstract = {3-Chloro-1-phenylpropan-1-ol and the corresponding butanoate, 3-chloro-1-phenyl-1-propyl butanoate, were kinetically resolved using lipase B from Candida antarctica catalysis by transesterification and hydrolysis respectively. The resulting chiral building blocks (S)- and (R)-3-chloro-1-phenylpropanol were converted into both enantiomers of the antidepressant drugs, Fluoxetine, Tomoxetine and Nisoxetine.}, author = {Liu, Hui-Ling and Hoff, Bard H. and Anthonsen, Thorleif}, citeulike-article-id = {4646488}, citeulike-linkout-0 = {http://dx.doi.org/10.1039/b000846j}, citeulike-linkout-1 = {http://www.rsc.org/Publishing/Journals/article.asp?doi=b000846j}, doi = {10.1039/b000846j}, journal = {J. Chem. Soc., Perkin Trans. 1}, keywords = {fluoxetine, lipase}, number = {11}, pages = {1767--1769}, posted-at = {2009-05-27 17:04:16}, priority = {2}, publisher = {The Royal Society of Chemistry}, title = {Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine}, url = {http://dx.doi.org/10.1039/b000846j}, year = {2000} }

TY - JOUR ID - citeulike:4646488 L3 - citeulike-article-id:4646488 N2 - 3-Chloro-1-phenylpropan-1-ol and the corresponding butanoate, 3-chloro-1-phenyl-1-propyl butanoate, were kinetically resolved using lipase B from Candida antarctica catalysis by transesterification and hydrolysis respectively. The resulting chiral building blocks (S)- and (R)-3-chloro-1-phenylpropanol were converted into both enantiomers of the antidepressant drugs, Fluoxetine, Tomoxetine and Nisoxetine. IS - 11 JF - J. Chem. Soc., Perkin Trans. 1 EP - 1769 TI - Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine PB - The Royal Society of Chemistry SP - 1767 KW - fluoxetine KW - lipase AU - Liu, Hui-Ling AU - Hoff, Bard AU - Anthonsen, Thorleif PY - 2000/// UR - http://dx.doi.org/10.1039/b000846j ER -