Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses Export

@article{citeulike:1229703, abstract = {A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. 10.1126/science.1139393}, author = {Chang, John T. and Palanivel, Vikram R. and Kinjyo, Ichiko and Schambach, Felix and Intlekofer, Andrew M. and Banerjee, Arnob and Longworth, Sarah A. and Vinup, Kristine E. and Mrass, Paul and Oliaro, Jane and Killeen, Nigel and Orange, Jordan S. and Russell, Sarah M. and Weninger, Wolfgang and Reiner, Steven L.}, booktitle = {Science}, citeulike-article-id = {1229703}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1139393}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/315/5819/1687}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17332376}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17332376}, day = {23}, doi = {10.1126/science.1139393}, journal = {Science}, keywords = {adapative, asymmetry, distal, effector, in, memory, polarity, proximal, tcell, transfer, vivo}, month = {March}, number = {5819}, pages = {1687--1691}, posted-at = {2008-10-06 19:38:51}, priority = {2}, title = {Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses}, url = {http://dx.doi.org/10.1126/science.1139393}, volume = {315}, year = {2007} }

TY - JOUR ID - citeulike:1229703 L3 - citeulike-article-id:1229703 N2 - A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before division. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. 10.1126/science.1139393 IS - 5819 JF - Science EP - 1691 TI - Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses VL - 315 T2 - Science SP - 1687 KW - adapative KW - asymmetry KW - distal KW - effector KW - in KW - memory KW - polarity KW - proximal KW - tcell KW - transfer KW - vivo AU - Chang, John AU - Palanivel, Vikram AU - Kinjyo, Ichiko AU - Schambach, Felix AU - Intlekofer, Andrew AU - Banerjee, Arnob AU - Longworth, Sarah AU - Vinup, Kristine AU - Mrass, Paul AU - Oliaro, Jane AU - Killeen, Nigel AU - Orange, Jordan AU - Russell, Sarah AU - Weninger, Wolfgang AU - Reiner, Steven PY - 2007/03/23/ UR - http://dx.doi.org/10.1126/science.1139393 ER -