CD27 Instructs CD4+ T Cells to Provide Help for the Memory CD8+ T Cell Response after Protein Immunization Export

@article{citeulike:3385389, abstract = {For optimal quality, memory CD8+ T cells require CD4+ T cell help. We have examined whether CD4+ T cells require CD27 to deliver this help, in a model of intranasal OVA protein immunization. CD27 deficiency reduced the capacity of CD4+ T cells to support Ag-specific CD8+ T cell accumulation at the tissue site after primary and secondary immunization. CD27-dependent CD4+ T cell help for the memory CD8+ T cell response was delivered during priming. It did not detectably affect formation of CD8+ memory T cells, but promoted their secondary expansion. CD27 improved survival of primed CD4+ T cells, but its contribution to the memory CD8+ T cell response relied on altered CD4+ T cell quality rather than quantity. CD27 induced a Th1-diagnostic gene expression profile in CD4+ T cells, which included the membrane molecule MS4A4B. Accordingly, CD27 increased the frequency of IFN-{gamma}- and IL-2-producing CD4+ T cells. It did not affect CD40L expression. Strikingly, MS4A4B was also identified as a unique marker of CD8+ memory T cells that had received CD27-proficient CD4+ T cell help during the primary response. This apparent imprinting effect suggests a role for MS4A4B as a downstream effector in CD27-dependent help for CD8+ T cell memory.}, author = {Xiao, Yanling and Peperzak, Victor and Keller, Anna M. and Borst, Jannie}, citeulike-article-id = {3385389}, citeulike-linkout-0 = {http://www.jimmunol.org/cgi/content/abstract/181/2/1071}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18606659}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18606659}, day = {15}, journal = {J Immunol}, keywords = {cd27, cd4, cd8, chandra, induction, ly116, marker, memory, ms4a4b, tcell, th1}, month = {July}, number = {2}, pages = {1071--1082}, posted-at = {2008-10-08 06:50:58}, priority = {2}, title = {CD27 Instructs CD4+ T Cells to Provide Help for the Memory CD8+ T Cell Response after Protein Immunization}, url = {http://www.jimmunol.org/cgi/content/abstract/181/2/1071}, volume = {181}, year = {2008} }

TY - JOUR ID - citeulike:3385389 L3 - citeulike-article-id:3385389 N2 - For optimal quality, memory CD8+ T cells require CD4+ T cell help. We have examined whether CD4+ T cells require CD27 to deliver this help, in a model of intranasal OVA protein immunization. CD27 deficiency reduced the capacity of CD4+ T cells to support Ag-specific CD8+ T cell accumulation at the tissue site after primary and secondary immunization. CD27-dependent CD4+ T cell help for the memory CD8+ T cell response was delivered during priming. It did not detectably affect formation of CD8+ memory T cells, but promoted their secondary expansion. CD27 improved survival of primed CD4+ T cells, but its contribution to the memory CD8+ T cell response relied on altered CD4+ T cell quality rather than quantity. CD27 induced a Th1-diagnostic gene expression profile in CD4+ T cells, which included the membrane molecule MS4A4B. Accordingly, CD27 increased the frequency of IFN-{gamma}- and IL-2-producing CD4+ T cells. It did not affect CD40L expression. Strikingly, MS4A4B was also identified as a unique marker of CD8+ memory T cells that had received CD27-proficient CD4+ T cell help during the primary response. This apparent imprinting effect suggests a role for MS4A4B as a downstream effector in CD27-dependent help for CD8+ T cell memory. IS - 2 JF - J Immunol EP - 1082 TI - CD27 Instructs CD4+ T Cells to Provide Help for the Memory CD8+ T Cell Response after Protein Immunization VL - 181 SP - 1071 KW - cd27 KW - cd4 KW - cd8 KW - chandra KW - induction KW - ly116 KW - marker KW - memory KW - ms4a4b KW - tcell KW - th1 AU - Xiao, Yanling AU - Peperzak, Victor AU - Keller, Anna AU - Borst, Jannie PY - 2008/07/15/ UR - http://www.jimmunol.org/cgi/content/abstract/181/2/1071 ER -