Late signals from CD27 prevent Fas-dependent apoptosis of primary CD8+ T cells. Export

@article{citeulike:3394672, abstract = {The role of costimulation has previously been confined to the very early stages of the CD8+ T cell response. In this study, we demonstrate the requirement for CD27 costimulation during the later phase, but not programming of the primary CD8+ T cell response to influenza virus and reveal a novel mechanism of action for CD27 costimulation. CD27 signals, during the later phase of the primary CD8+ T cell response, prevent apoptosis of Ag-specific CD8+ T cells. Blocking CD27L (CD70) on days 6 and 8 after infection reduces the number of NP(366-374)-specific CD8+ T cells, increases their sensitivity to CD95/Fas-mediated apoptosis, and up-regulates FasL on CD4+ T cells. This reduction of NP(366-374)-specific CD8+ T cells requires the presence of CD4+ T cells and Fas signaling. Lack of CD27 signals also decreases the quality of memory CD8+ T cell responses. Memory CD8+ T cells, which express surface CD27 similar to naive cells, however, do not require CD27 costimulation during a secondary response. Thus, CD27 acts indirectly to regulate primary Ag-specific CD8+ T cell responses by preventing apoptosis of CD8+ T cells during the later phase of the primary response and is required for optimal quality of memory cells, but is not required during normally primed secondary CD8+ T cell responses.}, author = {Dolfi, D. V. and Boesteanu, A. C. and Petrovas, C. and Xia, D. and Butz, E. A. and Katsikis, P. D.}, citeulike-article-id = {3394672}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18292513}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18292513}, day = {1}, issn = {0022-1767}, journal = {Journal of immunology (Baltimore, Md. : 1950)}, keywords = {apoptosis, cd27, cd4, cd8, differentiation, expression, fas, late, memory, primary}, month = {March}, number = {5}, pages = {2912--2921}, posted-at = {2008-10-10 22:12:40}, priority = {2}, title = {Late signals from CD27 prevent Fas-dependent apoptosis of primary CD8+ T cells.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18292513}, volume = {180}, year = {2008} }

TY - JOUR ID - citeulike:3394672 L3 - citeulike-article-id:3394672 N2 - The role of costimulation has previously been confined to the very early stages of the CD8+ T cell response. In this study, we demonstrate the requirement for CD27 costimulation during the later phase, but not programming of the primary CD8+ T cell response to influenza virus and reveal a novel mechanism of action for CD27 costimulation. CD27 signals, during the later phase of the primary CD8+ T cell response, prevent apoptosis of Ag-specific CD8+ T cells. Blocking CD27L (CD70) on days 6 and 8 after infection reduces the number of NP(366-374)-specific CD8+ T cells, increases their sensitivity to CD95/Fas-mediated apoptosis, and up-regulates FasL on CD4+ T cells. This reduction of NP(366-374)-specific CD8+ T cells requires the presence of CD4+ T cells and Fas signaling. Lack of CD27 signals also decreases the quality of memory CD8+ T cell responses. Memory CD8+ T cells, which express surface CD27 similar to naive cells, however, do not require CD27 costimulation during a secondary response. Thus, CD27 acts indirectly to regulate primary Ag-specific CD8+ T cell responses by preventing apoptosis of CD8+ T cells during the later phase of the primary response and is required for optimal quality of memory cells, but is not required during normally primed secondary CD8+ T cell responses. IS - 5 JF - Journal of immunology (Baltimore, Md. : 1950) SN - 0022-1767 EP - 2921 TI - Late signals from CD27 prevent Fas-dependent apoptosis of primary CD8+ T cells. VL - 180 SP - 2912 KW - apoptosis KW - cd27 KW - cd4 KW - cd8 KW - differentiation KW - expression KW - fas KW - late KW - memory KW - primary AU - Dolfi, DV AU - Boesteanu, AC AU - Petrovas, C AU - Xia, D AU - Butz, EA AU - Katsikis, PD PY - 2008/03/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18292513 ER -