Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. Export

@article{citeulike:3399305, abstract = {IL-2 is a cytokine with multiple and even divergent functions; it has been described as a key cytokine for in vitro T cell proliferation but is also essential for down-regulating T cell responses by inducing activation-induced cell death as well as regulatory T cells. The in vivo analysis of IL-2 function in regulating specific T cell responses has been hampered by the fact that mice deficient in IL-2 or its receptors develop lymphoproliferative diseases and/or autoimmunity. Here we generated chimeric mice harboring both IL-2R-competent and IL-2R-deficient T cells and assessed CD8+ T cell induction, function and maintenance after acute or persistent viral infections. Induction and maintenance of CD8+ T cells were relatively independent of IL-2R signaling during acute/resolved viral infection. In marked contrast, IL-2 was crucial for secondary expansion of memory CD8+ T cells and for the maintenance of virus-specific CD8+ T cells during persistent viral infections. Thus, depending on the chronicity of antigen exposure, IL-2R signaling is either essential or largely dispensable for induction and maintenance of virus-specific CD8+ T cell responses.}, author = {Bachmann, M. F. and Wolint, P. and Walton, S. and Schwarz, K. and Oxenius, A.}, citeulike-article-id = {3399305}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/eji.200637023}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17492805}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17492805}, doi = {10.1002/eji.200637023}, issn = {0014-2980}, journal = {European journal of immunology}, keywords = {acute, cd8, chronic, effector, il-2, il-2r, memory, primary, secondary, virus}, month = {June}, number = {6}, pages = {1502--1512}, posted-at = {2008-10-13 05:56:03}, priority = {2}, title = {Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.}, url = {http://dx.doi.org/10.1002/eji.200637023}, volume = {37}, year = {2007} }

TY - JOUR ID - citeulike:3399305 L3 - citeulike-article-id:3399305 N2 - IL-2 is a cytokine with multiple and even divergent functions; it has been described as a key cytokine for in vitro T cell proliferation but is also essential for down-regulating T cell responses by inducing activation-induced cell death as well as regulatory T cells. The in vivo analysis of IL-2 function in regulating specific T cell responses has been hampered by the fact that mice deficient in IL-2 or its receptors develop lymphoproliferative diseases and/or autoimmunity. Here we generated chimeric mice harboring both IL-2R-competent and IL-2R-deficient T cells and assessed CD8+ T cell induction, function and maintenance after acute or persistent viral infections. Induction and maintenance of CD8+ T cells were relatively independent of IL-2R signaling during acute/resolved viral infection. In marked contrast, IL-2 was crucial for secondary expansion of memory CD8+ T cells and for the maintenance of virus-specific CD8+ T cells during persistent viral infections. Thus, depending on the chronicity of antigen exposure, IL-2R signaling is either essential or largely dispensable for induction and maintenance of virus-specific CD8+ T cell responses. IS - 6 JF - European journal of immunology SN - 0014-2980 EP - 1512 TI - Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. VL - 37 SP - 1502 KW - acute KW - cd8 KW - chronic KW - effector KW - il-2 KW - il-2r KW - memory KW - primary KW - secondary KW - virus AU - Bachmann, MF AU - Wolint, P AU - Walton, S AU - Schwarz, K AU - Oxenius, A PY - 2007/06// UR - http://dx.doi.org/10.1002/eji.200637023 ER -