CD40-CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity. Export

@article{citeulike:3429942, abstract = {Tumor-specific immunity relies on interactions with the antigen receptors as well as costimulatory molecules, such as those of the CD28/B7 pathway and relatives of the TNFR gene family. Cytotoxic T lymphocytes specific for cellular antigens are in general primed by professional antigen-presenting cells that indirectly present antigens derived from cells in the periphery. This cross-priming of CD8(+) T cells requires signals provided by CD4(+) T helper cells. Although this dependency on [help' for efficient cytotoxic T lymphocyte priming has been well documented, it was only recently that more mechanistic insight into the nature of this event has been obtained. In the absence of the CD4(+) T cells, signalling through CD40 can replace 'help' required for priming of these CD8(+) T cells. These observations indicate that T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40Ligand (L) interactions, most likely through activation of professional antigen-presenting cells that cross-present cellular antigens to these T cells.}, author = {Toes, R. E. and Schoenberger, S. P. and van der Voort, E. I. and Offringa, R. and Melief, C. J.}, citeulike-article-id = {3429942}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/smim.1998.0147}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/9826577}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=9826577}, doi = {10.1006/smim.1998.0147}, issn = {1044-5323}, journal = {Seminars in immunology}, keywords = {cd4, cd40, cd40l, cd8, ctl, cytokines, dc, licensing, signal, tcell, three}, month = {December}, number = {6}, pages = {443--448}, posted-at = {2008-10-20 06:13:37}, priority = {2}, title = {CD40-CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity.}, url = {http://dx.doi.org/10.1006/smim.1998.0147}, volume = {10}, year = {1998} }

TY - JOUR ID - citeulike:3429942 L3 - citeulike-article-id:3429942 N2 - Tumor-specific immunity relies on interactions with the antigen receptors as well as costimulatory molecules, such as those of the CD28/B7 pathway and relatives of the TNFR gene family. Cytotoxic T lymphocytes specific for cellular antigens are in general primed by professional antigen-presenting cells that indirectly present antigens derived from cells in the periphery. This cross-priming of CD8(+) T cells requires signals provided by CD4(+) T helper cells. Although this dependency on [help' for efficient cytotoxic T lymphocyte priming has been well documented, it was only recently that more mechanistic insight into the nature of this event has been obtained. In the absence of the CD4(+) T cells, signalling through CD40 can replace 'help' required for priming of these CD8(+) T cells. These observations indicate that T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40Ligand (L) interactions, most likely through activation of professional antigen-presenting cells that cross-present cellular antigens to these T cells. IS - 6 JF - Seminars in immunology SN - 1044-5323 EP - 448 TI - CD40-CD40Ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity. VL - 10 SP - 443 KW - cd4 KW - cd40 KW - cd40l KW - cd8 KW - ctl KW - cytokines KW - dc KW - licensing KW - signal KW - tcell KW - three AU - Toes, RE AU - Schoenberger, SP AU - van der Voort, EI AU - Offringa, R AU - Melief, CJ PY - 1998/12// UR - http://dx.doi.org/10.1006/smim.1998.0147 ER -