A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Export

@article{citeulike:3437409, abstract = {The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation.}, author = {Bourgeois, C. and Rocha, B. and Tanchot, C.}, citeulike-article-id = {3437409}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1072615}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12242444}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12242444}, day = {20}, doi = {10.1126/science.1072615}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {cd4, cd40, cd8, direct, help, interaction, through}, month = {September}, number = {5589}, pages = {2060--2063}, posted-at = {2008-10-21 20:42:12}, priority = {2}, title = {A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.}, url = {http://dx.doi.org/10.1126/science.1072615}, volume = {297}, year = {2002} }

TY - JOUR ID - citeulike:3437409 L3 - citeulike-article-id:3437409 N2 - The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation. IS - 5589 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 2063 TI - A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. VL - 297 SP - 2060 KW - cd4 KW - cd40 KW - cd8 KW - direct KW - help KW - interaction KW - through AU - Bourgeois, C AU - Rocha, B AU - Tanchot, C PY - 2002/09/20/ UR - http://dx.doi.org/10.1126/science.1072615 ER -