Response of naïve and memory CD8+ T cells to antigen stimulation in vivo. Export

@article{citeulike:3438557, abstract = {We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the in vivo immune response of the same numbers of T cell receptor (TCR) transgenic (Tg) na\"{i}ve and memory T cells. Compared to na\"{i}ve Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and showed more rapid and efficient differentiation to effector functions. We found that initial na\"{i}ve T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T cells ensure the immediate control of reinfection.}, author = {Veiga-Fernandes, H. and Walter, U. and Bourgeois, C. and McLean, A. and Rocha, B.}, citeulike-article-id = {3438557}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/76907}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10881174}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10881174}, doi = {10.1038/76907}, issn = {1529-2908}, journal = {Nature immunology}, keywords = {antigen, cd8, in, memory, naive, response, stimulation, vivo}, month = {July}, number = {1}, pages = {47--53}, posted-at = {2008-10-22 21:24:50}, priority = {2}, title = {Response of na\"{i}ve and memory CD8+ T cells to antigen stimulation in vivo.}, url = {http://dx.doi.org/10.1038/76907}, volume = {1}, year = {2000} }

TY - JOUR ID - citeulike:3438557 L3 - citeulike-article-id:3438557 N2 - We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the in vivo immune response of the same numbers of T cell receptor (TCR) transgenic (Tg) naïve and memory T cells. Compared to naïve Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and showed more rapid and efficient differentiation to effector functions. We found that initial naïve T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T cells ensure the immediate control of reinfection. IS - 1 JF - Nature immunology SN - 1529-2908 EP - 53 TI - Response of naïve and memory CD8+ T cells to antigen stimulation in vivo. VL - 1 SP - 47 KW - antigen KW - cd8 KW - in KW - memory KW - naive KW - response KW - stimulation KW - vivo AU - Veiga-Fernandes, H AU - Walter, U AU - Bourgeois, C AU - McLean, A AU - Rocha, B PY - 2000/07// UR - http://dx.doi.org/10.1038/76907 ER -