Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Export

@article{citeulike:698623, abstract = {The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation na\"{i}ve CD8+ T cells become committed to dividing at least seven times and differentiating into effector and memory cells. Once the parental na\"{i}ve CD8+ T cell had been activated, this developmental process could not be interrupted and the daughter cells continued to divide and differentiate in the absence of further antigenic stimulation. These data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8+ T cell formation.}, address = {Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.}, author = {Kaech, S. M. and Ahmed, R.}, citeulike-article-id = {698623}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/87720}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11323695}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11323695}, doi = {10.1038/87720}, issn = {1529-2908}, journal = {Nat Immunol}, keywords = {cd8, development, encounter, initial, memory, naive, priming}, month = {May}, number = {5}, pages = {415--422}, posted-at = {2008-10-21 02:21:03}, priority = {2}, title = {Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in na\"{i}ve cells.}, url = {http://dx.doi.org/10.1038/87720}, volume = {2}, year = {2001} }

TY - JOUR ID - citeulike:698623 L3 - citeulike-article-id:698623 N2 - The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation naïve CD8+ T cells become committed to dividing at least seven times and differentiating into effector and memory cells. Once the parental naïve CD8+ T cell had been activated, this developmental process could not be interrupted and the daughter cells continued to divide and differentiate in the absence of further antigenic stimulation. These data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8+ T cell formation. IS - 5 JF - Nat Immunol SN - 1529-2908 AD - Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA. EP - 422 TI - Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. VL - 2 SP - 415 KW - cd8 KW - development KW - encounter KW - initial KW - memory KW - naive KW - priming AU - Kaech, SM AU - Ahmed, R PY - 2001/05// UR - http://dx.doi.org/10.1038/87720 ER -