Dopamine markers and general cognitive ability. Export

@article{ball98, abstract = {Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.}, author = {Ball, D. and Hill, L. and Eley, T. C. and Chorney, M. J. and Chorney, K. and Thompson, L. A. and Detterman, D. K. and Benbow, C. and Lubinski, D. and Owen, M. and Mcguffin, P. and Plomin, R.}, citeulike-article-id = {1436968}, journal = {Neuroreport}, keywords = {9507981, adolescent, alleles, biological, child, cognition, combinedbib, dna, dopamine, female, genetic, genotype, heritable, humans, intelligence, male, markers, polymorphism, quantitative, tests, trait}, month = {Jan}, number = {2}, pages = {347--349}, posted-at = {2007-07-05 14:54:12}, priority = {2}, title = {Dopamine markers and general cognitive ability.}, volume = {9}, year = {1998} }

TY - JOUR ID - ball98 L3 - citeulike-article-id:1436968 N2 - Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5. IS - 2 JF - Neuroreport EP - 349 TI - Dopamine markers and general cognitive ability. VL - 9 SP - 347 KW - 9507981 KW - adolescent KW - alleles KW - biological KW - child KW - cognition KW - combinedbib KW - dna KW - dopamine KW - female KW - genetic KW - genotype KW - heritable KW - humans KW - intelligence KW - male KW - markers KW - polymorphism KW - quantitative KW - tests KW - trait AU - Ball, D AU - Hill, L AU - Eley, TC AU - Chorney, MJ AU - Chorney, K AU - Thompson, LA AU - Detterman, DK AU - Benbow, C AU - Lubinski, D AU - Owen, M AU - Mcguffin, P AU - Plomin, R PY - 1998/Jan// ER -