Impact of family structure on the power of linkage tests using sib-pair methods. Export

@article{Goddard1999, abstract = {This analysis sought to determine the impact of specific ascertainment criteria based upon nuclear family affectation structures. Specifically, we evaluated the predicted and observed proportion of alleles shared identical by descent conditional on the number of affected and unaffected siblings in a pedigree, and compared sib-pair method linkage results under two ascertainment schemes, random vs. selected ascertainment, for this simulated complex genetic disease. These results suggest that samples differing in the composition of affected and unaffected siblings in the family will differ in their power to detect linkage. An effect of sampling scheme on power to map using affected-sib-pair methods should be considered when a reported linkage is not found in another study population.}, author = {Goddard, K. A. and Goode, E. L. and Rozek, L. S. and Jarvik, G. P.}, citeulike-article-id = {1437194}, journal = {Genet Epidemiol}, keywords = {10597495, combinedbib, family, genetic, genetics, govt, humans, linkage, lod, markers, models, non-us, phs, research, score, software, statistical, support, us}, number = {Suppl 1}, pages = {S575--9}, posted-at = {2007-07-05 14:55:02}, priority = {2}, title = {Impact of family structure on the power of linkage tests using sib-pair methods.}, volume = {17}, year = {1999} }

TY - JOUR ID - Goddard1999 L3 - citeulike-article-id:1437194 N2 - This analysis sought to determine the impact of specific ascertainment criteria based upon nuclear family affectation structures. Specifically, we evaluated the predicted and observed proportion of alleles shared identical by descent conditional on the number of affected and unaffected siblings in a pedigree, and compared sib-pair method linkage results under two ascertainment schemes, random vs. selected ascertainment, for this simulated complex genetic disease. These results suggest that samples differing in the composition of affected and unaffected siblings in the family will differ in their power to detect linkage. An effect of sampling scheme on power to map using affected-sib-pair methods should be considered when a reported linkage is not found in another study population. IS - Suppl 1 JF - Genet Epidemiol EP - 9 TI - Impact of family structure on the power of linkage tests using sib-pair methods. VL - 17 SP - S575 KW - 10597495 KW - combinedbib KW - family KW - genetic KW - genetics KW - govt KW - humans KW - linkage KW - lod KW - markers KW - models KW - non-us KW - phs KW - research KW - score KW - software KW - statistical KW - support KW - us AU - Goddard, KA AU - Goode, EL AU - Rozek, LS AU - Jarvik, GP PY - 1999/// ER -