Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder Export

@article{greenwood97:covariates, abstract = {Assessing heterogeneity in affected relative pair linkage analysis can help control type I error or identify important subgroups. We develop a method to incorporate covariates into sib-pair analysis, and hence are able to test for covariate effects on allele sharing in sib pairs. We propose a way of combining the five bipolar data sets to do a joint analysis of chromosome 18 data using this new method. Our results from a limited set of analyses do not show significant heterogeneity, and do not confirm the linkage previously identified on chromosome 18. (C) 1997 Wiley-Liss, Inc.}, annote = {genetics; covariates; genome scan; ASP; bipolar}, author = {Greenwood, C. M. T. and Bull, S. B.}, citeulike-article-id = {1437213}, keywords = {allele, chromosome-18, combinedbib, heterogeneity, imprinting, linkage, markers, of, origin, parent, regression, sharing, traits}, number = {6}, pages = {635--640}, posted-at = {2007-07-05 14:55:04}, priority = {2}, title = {Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder}, volume = {14}, year = {1997} }

TY - JOUR ID - greenwood97:covariates L3 - citeulike-article-id:1437213 N2 - Assessing heterogeneity in affected relative pair linkage analysis can help control type I error or identify important subgroups. We develop a method to incorporate covariates into sib-pair analysis, and hence are able to test for covariate effects on allele sharing in sib pairs. We propose a way of combining the five bipolar data sets to do a joint analysis of chromosome 18 data using this new method. Our results from a limited set of analyses do not show significant heterogeneity, and do not confirm the linkage previously identified on chromosome 18. (C) 1997 Wiley-Liss, Inc. IS - 6 EP - 640 TI - Incorporation of covariates into genome scanning using sib-pair analysis in bipolar affective disorder VL - 14 SP - 635 KW - allele KW - chromosome-18 KW - combinedbib KW - heterogeneity KW - imprinting KW - linkage KW - markers KW - of KW - origin KW - parent KW - regression KW - sharing KW - traits AU - Greenwood, CMT AU - Bull, SB PY - 1997/// ER -