Localization of a susceptibility gene for common forms of stroke to 5q12. Export

@article{gretarsdottir02, abstract = {Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.}, author = {Gretarsdottir, Solveig and Sveinbj\"{o}rnsdottir, Sigurlaug and Jonsson, Hj\"{o}rtur H. and Jakobsson, Finnbogi and Einarsdottir, Elisabet and Agnarsson, Uggi and Shkolny, Dana and Einarsson, Gisli and Gudjonsdottir, Herdis M. and Valdimarsson, Einar M. and Einarsson, Olafur B. and Thorgeirsson, Gudmundur and Hadzic, Radinka and Jonsdottir, Sif and Reynisdottir, Sigridur T. and Bjarnadottir, Sigrun M. and Gudmundsdottir, Thorunn and Gudlaugsdottir, Gudrun J. and Gill, Ramanjit and Lindpaintner, Klaus and Sainz, Jesus and Hannesson, Helgi H. and Sigurdsson, Gunnar T. and Frigge, Michael L. and Kong, Augustine and Gudnason, Vilmundur and Stefansson, Kari and Gulcher, Jeffrey R.}, citeulike-article-id = {1437214}, journal = {Am J Hum Genet}, keywords = {11833004, 5, accident, alleles, cerebrovascular, chromosome, chromosomes, combinedbib, complications, diabetes, disease, factors, female, genetic, genome, human, humans, hypercholesterolemia, hypertension, iceland, lod, male, mapping, markers, mellitus, pair, pedigree, predisposition, risk, score, to}, month = {Mar}, number = {3}, pages = {593--603}, posted-at = {2007-07-05 14:55:04}, priority = {2}, title = {Localization of a susceptibility gene for common forms of stroke to 5q12.}, volume = {70}, year = {2002} }

TY - JOUR ID - gretarsdottir02 L3 - citeulike-article-id:1437214 N2 - Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke. IS - 3 JF - Am J Hum Genet EP - 603 TI - Localization of a susceptibility gene for common forms of stroke to 5q12. VL - 70 SP - 593 KW - 11833004 KW - 5 KW - accident KW - alleles KW - cerebrovascular KW - chromosome KW - chromosomes KW - combinedbib KW - complications KW - diabetes KW - disease KW - factors KW - female KW - genetic KW - genome KW - human KW - humans KW - hypercholesterolemia KW - hypertension KW - iceland KW - lod KW - male KW - mapping KW - markers KW - mellitus KW - pair KW - pedigree KW - predisposition KW - risk KW - score KW - to AU - Gretarsdottir, Solveig AU - Sveinbjörnsdottir, Sigurlaug AU - Jonsson, Hjörtur AU - Jakobsson, Finnbogi AU - Einarsdottir, Elisabet AU - Agnarsson, Uggi AU - Shkolny, Dana AU - Einarsson, Gisli AU - Gudjonsdottir, Herdis AU - Valdimarsson, Einar AU - Einarsson, Olafur AU - Thorgeirsson, Gudmundur AU - Hadzic, Radinka AU - Jonsdottir, Sif AU - Reynisdottir, Sigridur AU - Bjarnadottir, Sigrun AU - Gudmundsdottir, Thorunn AU - Gudlaugsdottir, Gudrun AU - Gill, Ramanjit AU - Lindpaintner, Klaus AU - Sainz, Jesus AU - Hannesson, Helgi AU - Sigurdsson, Gunnar AU - Frigge, Michael AU - Kong, Augustine AU - Gudnason, Vilmundur AU - Stefansson, Kari AU - Gulcher, Jeffrey PY - 2002/Mar// ER -