Cost-effective analysis of candidate genes using htSNPs: a staged approach. Export

@article{lowe04, abstract = {We have previously shown that the selection of haplotype tag single nucleotide polymorphisms (htSNPs) and their statistical analysis in a multi-locus transmission/disequilibrium test (TDT) results in a more cost-effective genotyping strategy in disease association studies of genes by minimising redundancy due to linkage disequilibrium between SNPs. Further savings can be achieved by the use of a two-stage genotyping strategy. This approach is illustrated here in conjunction with the multi-locus TDT in determining whether common alleles of the immune regulatory genes RANK and its ligand TRANCE (RANKL) are associated with type 1 diabetes (T1D). A saving of approximately 75\% of potential genotyping reactions could be made with minimal loss of power. There was little evidence from our analysis for association between the TRANCE and RANK genes and T1D in the populations tested.}, author = {Lowe, C. E. and Cooper, J. D. and Chapman, J. M. and Barratt, B. J. and Twells and Green, E. A. and Savage, D. A. and Guja, C. and T\^{i}rgovi?te, Ionescu C. and Wolf, Tuomilehto E. and Tuomilehto, J. and Todd, J. A. and Clayton, D. G.}, citeulike-article-id = {1437382}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.gene.6364064}, doi = {10.1038/sj.gene.6364064}, journal = {Genes Immun}, keywords = {adolescent, and, carrier, case-control, child, combinedbib, cytoplasmic, diabetes, disease, disequilibrium, dna-binding, epistasis, female, genetic, genetics, genotype, glycoproteins, govt, haplotypes, humans, interleukin-13, interleukin-4, linkage, male, markers, mellitus, membrane, models, non-us, nuclear, nucleotide, polymorphism, population, predisposition, preschool, proteins, receptors, research, single, statistical, studies, support, to, trans-activators, type}, month = {Jun}, number = {4}, pages = {301--5}, posted-at = {2007-07-05 14:55:16}, priority = {2}, title = {Cost-effective analysis of candidate genes using ht{SNP}s: a staged approach.}, url = {10.1038/sj.gene.6364064}, volume = {5}, year = {2004} }

TY - JOUR ID - lowe04 L3 - citeulike-article-id:1437382 N2 - We have previously shown that the selection of haplotype tag single nucleotide polymorphisms (htSNPs) and their statistical analysis in a multi-locus transmission/disequilibrium test (TDT) results in a more cost-effective genotyping strategy in disease association studies of genes by minimising redundancy due to linkage disequilibrium between SNPs. Further savings can be achieved by the use of a two-stage genotyping strategy. This approach is illustrated here in conjunction with the multi-locus TDT in determining whether common alleles of the immune regulatory genes RANK and its ligand TRANCE (RANKL) are associated with type 1 diabetes (T1D). A saving of approximately 75\% of potential genotyping reactions could be made with minimal loss of power. There was little evidence from our analysis for association between the TRANCE and RANK genes and T1D in the populations tested. IS - 4 JF - Genes Immun EP - 5 TI - Cost-effective analysis of candidate genes using ht{SNP}s: a staged approach. VL - 5 SP - 301 KW - adolescent KW - and KW - carrier KW - case-control KW - child KW - combinedbib KW - cytoplasmic KW - diabetes KW - disease KW - disequilibrium KW - dna-binding KW - epistasis KW - female KW - genetic KW - genetics KW - genotype KW - glycoproteins KW - govt KW - haplotypes KW - humans KW - interleukin-13 KW - interleukin-4 KW - linkage KW - male KW - markers KW - mellitus KW - membrane KW - models KW - non-us KW - nuclear KW - nucleotide KW - polymorphism KW - population KW - predisposition KW - preschool KW - proteins KW - receptors KW - research KW - single KW - statistical KW - studies KW - support KW - to KW - trans-activators KW - type AU - Lowe, CE AU - Cooper, JD AU - Chapman, JM AU - Barratt, BJ AU - Twells AU - Green, EA AU - Savage, DA AU - Guja, C AU - Tîrgovi?te, Ionescu AU - Wolf, Tuomilehto AU - Tuomilehto, J AU - Todd, JA AU - Clayton, DG PY - 2004/Jun// UR - http://dx.doi.org/10.1038/sj.gene.6364064 ER -