Genetical genomics in humans and model organisms.

@article{citeulike:920451, abstract = {Genetical genomics has been proposed to map loci controlling gene-expression differences (eQTLs) that might underlie functional trait variation. We briefly review the studies in model species and conclude that, although they successfully demonstrate the utility of genetical genomics, they are too limited to unlock the full potential of this approach and some results should be interpreted with caution. We subsequently elaborate on two recent studies that use this approach in humans. The many differences between these studies complicate meaningful comparisons between them. A joint analysis of the two experiments offers some scope for more powerful genetical genomics.}, address = {The Roslin Institute, Roslin, Midlothian EH25 9PS, Scotland, UK. DJ.deKoning@BBSRC.ac.uk}, author = {de Koning, D. J. and Haley, C. S.}, citeulike-article-id = {920451}, doi = {10.1016/j.tig.2005.05.004}, issn = {0168-9525}, journal = {Trends Genet}, keywords = {expression, statistics}, month = {July}, number = {7}, pages = {377--381}, posted-at = {2007-08-31 09:51:15}, priority = {2}, title = {Genetical genomics in humans and model organisms.}, url = {http://dx.doi.org/10.1016/j.tig.2005.05.004}, volume = {21}, year = {2005} }

TY - JOUR ID - citeulike:920451 L3 - citeulike-article-id:920451 N2 - Genetical genomics has been proposed to map loci controlling gene-expression differences (eQTLs) that might underlie functional trait variation. We briefly review the studies in model species and conclude that, although they successfully demonstrate the utility of genetical genomics, they are too limited to unlock the full potential of this approach and some results should be interpreted with caution. We subsequently elaborate on two recent studies that use this approach in humans. The many differences between these studies complicate meaningful comparisons between them. A joint analysis of the two experiments offers some scope for more powerful genetical genomics. IS - 7 JF - Trends Genet SN - 0168-9525 AD - The Roslin Institute, Roslin, Midlothian EH25 9PS, Scotland, UK. DJ.deKoning@BBSRC.ac.uk EP - 381 TI - Genetical genomics in humans and model organisms. VL - 21 SP - 377 KW - expression KW - statistics AU - de Koning, DJ AU - Haley, CS PY - 2005/07// UR - http://dx.doi.org/10.1016/j.tig.2005.05.004 ER -