Extreme genomic variation in a natural population Export

@article{citeulike:1203732, abstract = {10.1073/pnas.0700890104 Whole-genome sequence data from samples of natural populations provide fertile grounds for analyses of intraspecific variation and tests of population genetic theory. We show that the urochordate , one of the species of ocean-dwelling broadcast spawners commonly known as sea squirts, exhibits the highest rates of single-nucleotide and structural polymorphism ever comprehensively quantified in a multicellular organism. We demonstrate that the cause for the extreme heterozygosity is a large effective population size, and, consistent with prediction by the neutral theory, we find evidence of strong purifying selection. These results constitute in-depth insight into the dynamics of highly polymorphic genomes and provide important empirical support of population genetic theory as it pertains to population size, heterozygosity, and natural selection.}, author = {Small, Kerrin S. and Brudno, Michael and Hill, Matthew M. and Sidow, Arend}, citeulike-article-id = {1203732}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0700890104}, citeulike-linkout-1 = {http://www.pnas.org/content/104/13/5698.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/104/13/5698.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/104/13/5698}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17372217}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17372217}, day = {27}, doi = {10.1073/pnas.0700890104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {biology, evolution, genetics}, month = {March}, number = {13}, pages = {5698--5703}, posted-at = {2009-10-27 05:17:00}, priority = {2}, title = {Extreme genomic variation in a natural population}, url = {http://dx.doi.org/10.1073/pnas.0700890104}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:1203732 L3 - citeulike-article-id:1203732 N2 - 10.1073/pnas.0700890104 Whole-genome sequence data from samples of natural populations provide fertile grounds for analyses of intraspecific variation and tests of population genetic theory. We show that the urochordate , one of the species of ocean-dwelling broadcast spawners commonly known as sea squirts, exhibits the highest rates of single-nucleotide and structural polymorphism ever comprehensively quantified in a multicellular organism. We demonstrate that the cause for the extreme heterozygosity is a large effective population size, and, consistent with prediction by the neutral theory, we find evidence of strong purifying selection. These results constitute in-depth insight into the dynamics of highly polymorphic genomes and provide important empirical support of population genetic theory as it pertains to population size, heterozygosity, and natural selection. IS - 13 JF - Proceedings of the National Academy of Sciences EP - 5703 TI - Extreme genomic variation in a natural population VL - 104 SP - 5698 KW - biology KW - evolution KW - genetics AU - Small, Kerrin AU - Brudno, Michael AU - Hill, Matthew AU - Sidow, Arend PY - 2007/03/27/ UR - http://dx.doi.org/10.1073/pnas.0700890104 ER -