Beyond the Sequence: Cellular Organization of Genome Function Export

@article{citeulike:1428292, abstract = {Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the spatial arrangement of genomes within the cell nucleus. Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability.}, address = {National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov}, author = {Misteli, T.}, citeulike-article-id = {1428292}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2007.01.028}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867407001262}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17320514}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17320514}, day = {23}, doi = {10.1016/j.cell.2007.01.028}, issn = {00928674}, journal = {Cell}, keywords = {cellular, function, genome, organization, review}, month = {February}, number = {4}, pages = {787--800}, posted-at = {2007-07-02 10:41:59}, priority = {2}, title = {Beyond the Sequence: Cellular Organization of Genome Function}, url = {http://dx.doi.org/10.1016/j.cell.2007.01.028}, volume = {128}, year = {2007} }

TY - JOUR ID - citeulike:1428292 L3 - citeulike-article-id:1428292 N2 - Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the spatial arrangement of genomes within the cell nucleus. Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability. IS - 4 JF - Cell SN - 00928674 AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov EP - 800 TI - Beyond the Sequence: Cellular Organization of Genome Function VL - 128 SP - 787 KW - cellular KW - function KW - genome KW - organization KW - review AU - Misteli, T PY - 2007/02/23/ UR - http://dx.doi.org/10.1016/j.cell.2007.01.028 ER -