Ultradian metronome: timekeeper for orchestration of cellular coherence. Export

@article{citeulike:1680117, abstract = {Dynamic intracellular spatial and temporal organization emerges from spontaneous synchronization of a massive array of weakly coupled oscillators; the majority of subcellular processes are implicated in this integrated expression of cellular physiology. Evidence for this view comes mainly from studies of Saccharomyces cerevisiae growing in self-synchronized continuous cultures, in which a temperature-compensated ultradian clock (period of approximately 40 min) couples fermentation with redox state in addition to the transcriptome and cell-division-cycle progression. Functions for ultradian clocks have also been determined in other yeasts (e.g. Schizosaccharomyces pombe and Candida utilis), seven protists (e.g. Acanthamoeba castellanii and Paramecium tetraurelia), as well as cultured mammalian cells. We suggest that ultradian timekeeping is a basic universal necessity for coordinated intracellular coherence.}, address = {Microbiology (BIOSI 1), Cardiff University, P O Box 915, Cardiff, CF10 3TL, UK. lloydd@cardiff.ac.uk}, author = {Lloyd, D. and Murray, D. B.}, citeulike-article-id = {1680117}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tibs.2005.05.005}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15935677}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15935677}, doi = {10.1016/j.tibs.2005.05.005}, issn = {0968-0004}, journal = {Trends Biochem Sci}, keywords = {cell, cellular, clock, coherence, cycle, synchrony, ultradian}, month = {July}, number = {7}, pages = {373--377}, posted-at = {2007-09-20 19:21:25}, priority = {2}, title = {Ultradian metronome: timekeeper for orchestration of cellular coherence.}, url = {http://dx.doi.org/10.1016/j.tibs.2005.05.005}, volume = {30}, year = {2005} }

TY - JOUR ID - citeulike:1680117 L3 - citeulike-article-id:1680117 N2 - Dynamic intracellular spatial and temporal organization emerges from spontaneous synchronization of a massive array of weakly coupled oscillators; the majority of subcellular processes are implicated in this integrated expression of cellular physiology. Evidence for this view comes mainly from studies of Saccharomyces cerevisiae growing in self-synchronized continuous cultures, in which a temperature-compensated ultradian clock (period of approximately 40 min) couples fermentation with redox state in addition to the transcriptome and cell-division-cycle progression. Functions for ultradian clocks have also been determined in other yeasts (e.g. Schizosaccharomyces pombe and Candida utilis), seven protists (e.g. Acanthamoeba castellanii and Paramecium tetraurelia), as well as cultured mammalian cells. We suggest that ultradian timekeeping is a basic universal necessity for coordinated intracellular coherence. IS - 7 JF - Trends Biochem Sci SN - 0968-0004 AD - Microbiology (BIOSI 1), Cardiff University, P O Box 915, Cardiff, CF10 3TL, UK. lloydd@cardiff.ac.uk EP - 377 TI - Ultradian metronome: timekeeper for orchestration of cellular coherence. VL - 30 SP - 373 KW - cell KW - cellular KW - clock KW - coherence KW - cycle KW - synchrony KW - ultradian AU - Lloyd, D AU - Murray, DB PY - 2005/07// UR - http://dx.doi.org/10.1016/j.tibs.2005.05.005 ER -