Structural intermediates in microtubule assembly and disassembly: how and why? Export

@article{citeulike:555224, abstract = {Microtubules are cytoskeletal polymers made of repeating [alpha][beta]-tubulin heterodimers that play essential roles in all eukaryotic cells. The complex dynamic behavior of microtubules, which is ultimately due to the tubulin subunit structure and its intrinsic GTPase activity, is key to the functions of these ubiquitous polymers. Microtubule assembly and disassembly do not take place by simple helical growth and shrinkage via individual subunits, but rather involve transient polymer intermediates, distinct from the microtubule, without parallel in other biological self-assembly systems. The discovery of these intermediates a decade ago has been followed recently by quantitative descriptions of their structure and their relationship to nucleotide state.}, author = {Nogales, Eva and Wang, Hong-Wei}, booktitle = {Cell regulation}, citeulike-article-id = {555224}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ceb.2006.02.009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16495041}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16495041}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6VRW-4J9X2T0-1/2/b3b453b87a8d5307941932d41e9e8c3b}, doi = {10.1016/j.ceb.2006.02.009}, journal = {Current Opinion in Cell Biology}, keywords = {assembly, disassembly, intermediates, microtubule, structure}, month = {April}, number = {2}, pages = {179--184}, posted-at = {2007-07-12 04:39:49}, priority = {2}, title = {Structural intermediates in microtubule assembly and disassembly: how and why?}, url = {http://dx.doi.org/10.1016/j.ceb.2006.02.009}, volume = {18}, year = {2006} }

TY - JOUR ID - citeulike:555224 L3 - citeulike-article-id:555224 N2 - Microtubules are cytoskeletal polymers made of repeating [alpha][beta]-tubulin heterodimers that play essential roles in all eukaryotic cells. The complex dynamic behavior of microtubules, which is ultimately due to the tubulin subunit structure and its intrinsic GTPase activity, is key to the functions of these ubiquitous polymers. Microtubule assembly and disassembly do not take place by simple helical growth and shrinkage via individual subunits, but rather involve transient polymer intermediates, distinct from the microtubule, without parallel in other biological self-assembly systems. The discovery of these intermediates a decade ago has been followed recently by quantitative descriptions of their structure and their relationship to nucleotide state. IS - 2 JF - Current Opinion in Cell Biology EP - 184 TI - Structural intermediates in microtubule assembly and disassembly: how and why? VL - 18 T2 - Cell regulation SP - 179 KW - assembly KW - disassembly KW - intermediates KW - microtubule KW - structure AU - Nogales, Eva AU - Wang, Hong-Wei PY - 2006/04// UR - http://dx.doi.org/10.1016/j.ceb.2006.02.009 ER -