Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays Export

@inproceedings{citeulike:3839302, abstract = {This paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flexibility and reliability. The sensitivity is improved significantly by suppressing the output offset through pseudo-differential operation, using R-C components for the reference impedance. The sensing and reference electrodes are excited with low-amplitude differential voltage pulses and the current response to membrane resistance (R<inf>M</inf>) change of the tBLM biosensor is converted to voltage by a precision, low-noise SC integrator available as a single-package IC. Tests with both electrical models and actual biosensors demonstrated that the proposed circuit operates with high sensitivity and can be used in single chip versions for low-cost and high-sensitive tBLM biosensor arrays, featuring multiple electrode sites.}, author = {Temiz, Yuksel and Gurkaynak, Frank K. and Terrettaz, Samuel and Vogel, Horst and De Micheli, Giovanni and Leblebici, Yusuf and Guiducci, Carlotta and Benini, Luca}, booktitle = {Sensors, IEEE}, citeulike-article-id = {3839302}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/ICSENS.2008.4716525}, citeulike-linkout-1 = {http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4716525}, comment = {Interrogate a tBLM using a matched impedance to cancel the baseline. }, doi = {10.1109/ICSENS.2008.4716525}, journal = {Sensors, IEEE}, keywords = {baseline, blm, cancellation}, month = {October}, pages = {650--653}, posted-at = {2008-12-31 16:13:01}, priority = {0}, title = {Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays}, url = {http://dx.doi.org/10.1109/ICSENS.2008.4716525}, year = {2008} }

TY - CONF ID - citeulike:3839302 L3 - citeulike-article-id:3839302 N2 - This paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flexibility and reliability. The sensitivity is improved significantly by suppressing the output offset through pseudo-differential operation, using R-C components for the reference impedance. The sensing and reference electrodes are excited with low-amplitude differential voltage pulses and the current response to membrane resistance (R<inf>M</inf>) change of the tBLM biosensor is converted to voltage by a precision, low-noise SC integrator available as a single-package IC. Tests with both electrical models and actual biosensors demonstrated that the proposed circuit operates with high sensitivity and can be used in single chip versions for low-cost and high-sensitive tBLM biosensor arrays, featuring multiple electrode sites. JF - Sensors, IEEE EP - 653 TI - Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays T2 - Sensors, IEEE SP - 650 KW - baseline KW - blm KW - cancellation N1 - Interrogate a tBLM using a matched impedance to cancel the baseline. AU - Temiz, Yuksel AU - Gurkaynak, Frank AU - Terrettaz, Samuel AU - Vogel, Horst AU - De Micheli, Giovanni AU - Leblebici, Yusuf AU - Guiducci, Carlotta AU - Benini, Luca PY - 2008/10// UR - http://dx.doi.org/10.1109/ICSENS.2008.4716525 ER -