Membrane protein biosensor with multi-channel CMOS impedance extractor and digitizer Export

@inproceedings{citeulike:3866347, abstract = {Recent advances in the self-assembly of biomimetic interfaces permit the development of biosensor arrays that harness the unique sensitivity and selectivity of membrane proteins. Integrating these interfaces into microsystem platforms for point-of-care and high throughput screening applications requires compact, multi-channel readout circuitry to measure interface impedance over a broad frequency spectrum. This paper described the design and characterization of a biosensor array microsystem comprised of a new CMOS impedance extractor and digitizer (IED) circuit and tethered bilayer lipid membranes (tBLM) incorporated with gramicidin ion channel proteins. The extremely hardware efficient mixed-signal IED circuit measures the response of a tBLM interface, extracts its real and imaginary impedance components, and digitizes and stores the results. Occupying only 0.06mm², the IED circuit can be instantiated more than 100 times in a single 3mm \&\#x00D7; 3mm chip, making it well suited for simultaneous readout of a variety of monolithic sensor arrays.}, author = {Yang, Chao and Mason, Andrew J.}, booktitle = {Sensors, 2008 IEEE}, citeulike-article-id = {3866347}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/ICSENS.2008.4716523}, citeulike-linkout-1 = {http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4716523}, comment = {Chao's Gen. 1 IDC: chopper \& two counters}, doi = {10.1109/ICSENS.2008.4716523}, journal = {Sensors, 2008 IEEE}, keywords = {fra, impedance}, pages = {642--645}, posted-at = {2009-01-09 00:41:55}, priority = {0}, title = {Membrane protein biosensor with multi-channel CMOS impedance extractor and digitizer}, url = {http://dx.doi.org/10.1109/ICSENS.2008.4716523}, year = {2008} }

TY - CONF ID - citeulike:3866347 L3 - citeulike-article-id:3866347 N2 - Recent advances in the self-assembly of biomimetic interfaces permit the development of biosensor arrays that harness the unique sensitivity and selectivity of membrane proteins. Integrating these interfaces into microsystem platforms for point-of-care and high throughput screening applications requires compact, multi-channel readout circuitry to measure interface impedance over a broad frequency spectrum. This paper described the design and characterization of a biosensor array microsystem comprised of a new CMOS impedance extractor and digitizer (IED) circuit and tethered bilayer lipid membranes (tBLM) incorporated with gramicidin ion channel proteins. The extremely hardware efficient mixed-signal IED circuit measures the response of a tBLM interface, extracts its real and imaginary impedance components, and digitizes and stores the results. Occupying only 0.06mm², the IED circuit can be instantiated more than 100 times in a single 3mm × 3mm chip, making it well suited for simultaneous readout of a variety of monolithic sensor arrays. JF - Sensors, 2008 IEEE EP - 645 TI - Membrane protein biosensor with multi-channel CMOS impedance extractor and digitizer T2 - Sensors, 2008 IEEE SP - 642 KW - fra KW - impedance N1 - Chao's Gen. 1 IDC: chopper & two counters AU - Yang, Chao AU - Mason, Andrew PY - 2008/// UR - http://dx.doi.org/10.1109/ICSENS.2008.4716523 ER -