An instrument-on-chip for impedance measurements on nanobiosensors with attoFarad resoution Export

@inproceedings{citeulike:4712663, abstract = {Impedance measurements play a fundamental role in biotechnology, serving both as an investigation tool and as a direct detection technique. Tracking impedance over time is extensively used for spatial monitoring, imaging, counting, sizing (Coulter counter) and sorting cells (flow cytometry) both in macro and microfluidic systems [1]. Other than cellular biology, impedance measurements are largely used also in molecular biology to operate affinity molecular biosensors [2], where impedance measurements are used to detect the binding of a target molecule to highly specific biological macromolecules such as antibodies, receptors, enzymes and DNA strands. Downscaling these systems to nanoscale dimensions would offer tremendous advantages as compared to the currently existing macro and microscale counterparts on three essential aspects, namely sensitivity (detection of single molecule binding events), response time (more efficient diffusion of the analyte) and amount of sample analyte [3]. Monitoring single molecules implies very small absolute impedance variations, on the order of a few attoFarads for the capacitive term, which should be detected by applying only a few tens of millivolts to avoid stressing the macromolecule with high electrical fields.}, author = {Gozzini, Fabio and Ferrari, Giorgio and Sampietro, Marco}, booktitle = {Solid-State Circuits Conference - Digest of Technical Papers, 2009. ISSCC 2009. IEEE International}, citeulike-article-id = {4712663}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/ISSCC.2009.4977450}, citeulike-linkout-1 = {http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4977450}, comment = {Integrator style I to V is used because it is low noise, the problem is saturating the cap. The dual feedback provides a dual band output (0-100Hz and 100-1MHz).}, doi = {10.1109/ISSCC.2009.4977450}, journal = {Solid-State Circuits Conference - Digest of Technical Papers, 2009. ISSCC 2009. IEEE International}, keywords = {impedance, mtg\_reading}, pages = {346--347,347a}, posted-at = {2009-06-02 00:50:35}, priority = {5}, title = {An instrument-on-chip for impedance measurements on nanobiosensors with attoFarad resoution}, url = {http://dx.doi.org/10.1109/ISSCC.2009.4977450}, year = {2009} }

TY - CONF ID - citeulike:4712663 L3 - citeulike-article-id:4712663 N2 - Impedance measurements play a fundamental role in biotechnology, serving both as an investigation tool and as a direct detection technique. Tracking impedance over time is extensively used for spatial monitoring, imaging, counting, sizing (Coulter counter) and sorting cells (flow cytometry) both in macro and microfluidic systems [1]. Other than cellular biology, impedance measurements are largely used also in molecular biology to operate affinity molecular biosensors [2], where impedance measurements are used to detect the binding of a target molecule to highly specific biological macromolecules such as antibodies, receptors, enzymes and DNA strands. Downscaling these systems to nanoscale dimensions would offer tremendous advantages as compared to the currently existing macro and microscale counterparts on three essential aspects, namely sensitivity (detection of single molecule binding events), response time (more efficient diffusion of the analyte) and amount of sample analyte [3]. Monitoring single molecules implies very small absolute impedance variations, on the order of a few attoFarads for the capacitive term, which should be detected by applying only a few tens of millivolts to avoid stressing the macromolecule with high electrical fields. JF - Solid-State Circuits Conference - Digest of Technical Papers, 2009. ISSCC 2009. IEEE International EP - 347,347a TI - An instrument-on-chip for impedance measurements on nanobiosensors with attoFarad resoution T2 - Solid-State Circuits Conference - Digest of Technical Papers, 2009. ISSCC 2009. IEEE International SP - 346 KW - impedance KW - mtg_reading N1 - Integrator style I to V is used because it is low noise, the problem is saturating the cap. The dual feedback provides a dual band output (0-100Hz and 100-1MHz). AU - Gozzini, Fabio AU - Ferrari, Giorgio AU - Sampietro, Marco PY - 2009/// UR - http://dx.doi.org/10.1109/ISSCC.2009.4977450 ER -