The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis? Export

@article{citeulike:2746060, abstract = {Aging is the most important risk factor for common neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Aging in the central nervous system has been associated with elevated mutation load in mitochondrial DNA, defects in mitochondrial respiration and increased oxidative damage. These observations support a [`]vicious cycle' theory which states that there is a feedback mechanism connecting these events in aging and age-associated neurodegeneration. Despite being an extremely attractive hypothesis, the bulk of the evidence supporting the mitochondrial vicious cycle model comes from pharmacological experiments in which the modes of mitochondrial enzyme inhibition are far from those observed in real life. Furthermore, recent in vivo evidence does not support this model. In this review, we focus on the relationship among the components of the putative vicious cycle, with particular emphasis on the role of mitochondrial defects on oxidative stress.}, author = {Fukui, Hirokazu and Moraes, Carlos T.}, citeulike-article-id = {2746060}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tins.2008.02.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18403030}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18403030}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T0V-4S7S19R-3/1/845c981a80b6f8873143d9da731781e0}, doi = {10.1016/j.tins.2008.02.008}, journal = {Trends in Neurosciences}, keywords = {aging, defect, disease, goodref, litrev, mitochondria, mtdna, respiration, review, ros}, month = {May}, number = {5}, pages = {251--256}, posted-at = {2009-04-24 09:28:06}, priority = {0}, title = {The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?}, url = {http://dx.doi.org/10.1016/j.tins.2008.02.008}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:2746060 L3 - citeulike-article-id:2746060 N2 - Aging is the most important risk factor for common neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Aging in the central nervous system has been associated with elevated mutation load in mitochondrial DNA, defects in mitochondrial respiration and increased oxidative damage. These observations support a [`]vicious cycle' theory which states that there is a feedback mechanism connecting these events in aging and age-associated neurodegeneration. Despite being an extremely attractive hypothesis, the bulk of the evidence supporting the mitochondrial vicious cycle model comes from pharmacological experiments in which the modes of mitochondrial enzyme inhibition are far from those observed in real life. Furthermore, recent in vivo evidence does not support this model. In this review, we focus on the relationship among the components of the putative vicious cycle, with particular emphasis on the role of mitochondrial defects on oxidative stress. IS - 5 JF - Trends in Neurosciences EP - 256 TI - The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis? VL - 31 SP - 251 KW - aging KW - defect KW - disease KW - goodref KW - litrev KW - mitochondria KW - mtdna KW - respiration KW - review KW - ros AU - Fukui, Hirokazu AU - Moraes, Carlos PY - 2008/05// UR - http://dx.doi.org/10.1016/j.tins.2008.02.008 ER -