Yeast genomics and proteomics in drug discovery and target validation. Export

@article{citeulike:4181083, abstract = {Small, cell permeable, and target-specific chemical ligands are highly valuable, not only as therapeutics but also as research tools. The synthesis, identification and characterization of these compounds is often a difficult task. The straightforward genetics of the budding yeast Saccharomyces cerevisiae, and the high degree of conservation of basic cellular processes between yeast and higher organisms makes yeast an excellent tool for drug development studies, particularly in regards to anticancer and anti-fungal drug discovery. Recent advances in yeast functional genomics and proteomics studies are changing the field of yeast research. Many of these new technologies are readily applicable to drug target identification and other aspects of drug discovery. This review will focus on current genetic, genomic, and proteomic methodologies in S. cerevisiae that have the potential to be useful in drug discovery and target validation.}, author = {Parsons, A. B. and Geyer, R. and Hughes, T. R. and Boone, C.}, citeulike-article-id = {4181083}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/14593709}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=14593709}, issn = {1087-2957}, journal = {Progress in cell cycle research}, keywords = {chemgen, genomics, projnarp, proteomics, review, yeast}, pages = {159--166}, posted-at = {2009-03-16 10:39:12}, priority = {3}, title = {Yeast genomics and proteomics in drug discovery and target validation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14593709}, volume = {5}, year = {2003} }

TY - JOUR ID - citeulike:4181083 L3 - citeulike-article-id:4181083 N2 - Small, cell permeable, and target-specific chemical ligands are highly valuable, not only as therapeutics but also as research tools. The synthesis, identification and characterization of these compounds is often a difficult task. The straightforward genetics of the budding yeast Saccharomyces cerevisiae, and the high degree of conservation of basic cellular processes between yeast and higher organisms makes yeast an excellent tool for drug development studies, particularly in regards to anticancer and anti-fungal drug discovery. Recent advances in yeast functional genomics and proteomics studies are changing the field of yeast research. Many of these new technologies are readily applicable to drug target identification and other aspects of drug discovery. This review will focus on current genetic, genomic, and proteomic methodologies in S. cerevisiae that have the potential to be useful in drug discovery and target validation. JF - Progress in cell cycle research SN - 1087-2957 EP - 166 TI - Yeast genomics and proteomics in drug discovery and target validation. VL - 5 SP - 159 KW - chemgen KW - genomics KW - projnarp KW - proteomics KW - review KW - yeast AU - Parsons, AB AU - Geyer, R AU - Hughes, TR AU - Boone, C PY - 2003/// UR - http://view.ncbi.nlm.nih.gov/pubmed/14593709 ER -