The Sod2 mutant mouse as a model for oxidative stress: A functional proteomics perspective. Export

@article{citeulike:4732028, abstract = {Oxidative stress has been implicated in the pathogenesis of numerous human diseases and disorders, but the mechanistic basis often remains enigmatic. The Sod2 mutant mouse, which is sensitized to mitochondrial stress, is an ideal mutant model for studying the role of oxidative stress in a diverse range of complications arising from mitochondrial dysfunction and diminished antioxidant defense. To fully appreciate the widespread molecular consequences under increased oxidative stress, a systems approach utilizing proteomics is able to provide a global overview of the complex biological changes, which a targeted single biomolecular approach cannot address fully. This review focuses on the applications of mass spectrometry and functional proteomics in the Sod2 mouse. The combinatorial approach provides novel insights into the interplay of chemistry and biology, free radicals and proteins, thereby augmenting our understanding of how redox perturbations influence protein dynamics. Ultimately, this knowledge can lead to the development of free radical-targeted therapies. (c) 2009 Wiley Periodicals, Inc., Mass Spec Rev.}, author = {Lee, Yie Hou H. and Lin, Qingsong and Boelsterli, Urs A A. and Chung, Maxey C M C.}, citeulike-article-id = {4732028}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mas.20226}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19294730}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19294730}, day = {17}, doi = {10.1002/mas.20226}, issn = {1098-2787}, journal = {Mass spectrometry reviews}, keywords = {deletion, goodref, model, mouse, mutant, proteomics, ros}, month = {March}, posted-at = {2009-06-03 12:49:34}, priority = {2}, title = {The Sod2 mutant mouse as a model for oxidative stress: A functional proteomics perspective.}, url = {http://dx.doi.org/10.1002/mas.20226}, year = {2009} }

TY - JOUR ID - citeulike:4732028 L3 - citeulike-article-id:4732028 N2 - Oxidative stress has been implicated in the pathogenesis of numerous human diseases and disorders, but the mechanistic basis often remains enigmatic. The Sod2 mutant mouse, which is sensitized to mitochondrial stress, is an ideal mutant model for studying the role of oxidative stress in a diverse range of complications arising from mitochondrial dysfunction and diminished antioxidant defense. To fully appreciate the widespread molecular consequences under increased oxidative stress, a systems approach utilizing proteomics is able to provide a global overview of the complex biological changes, which a targeted single biomolecular approach cannot address fully. This review focuses on the applications of mass spectrometry and functional proteomics in the Sod2 mouse. The combinatorial approach provides novel insights into the interplay of chemistry and biology, free radicals and proteins, thereby augmenting our understanding of how redox perturbations influence protein dynamics. Ultimately, this knowledge can lead to the development of free radical-targeted therapies. (c) 2009 Wiley Periodicals, Inc., Mass Spec Rev. JF - Mass spectrometry reviews SN - 1098-2787 TI - The Sod2 mutant mouse as a model for oxidative stress: A functional proteomics perspective. KW - deletion KW - goodref KW - model KW - mouse KW - mutant KW - proteomics KW - ros AU - Lee, Yie Hou AU - Lin, Qingsong AU - Boelsterli, Urs A AU - Chung, Maxey C M PY - 2009/03/17/ UR - http://dx.doi.org/10.1002/mas.20226 ER -