Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability. Export

@article{citeulike:2547742, abstract = {Transmural dispersion in action potential duration (APD) has been shown to contribute to arrhythmia induction in the heart. However, its role in termination of lethal arrhythmias by defibrillation shocks has never been examined. The goal of this study is to investigate how transmural dispersion in APD affects cardiac vulnerability to electric shocks, in an attempt to better understand the mechanisms behind defibrillation failure. This study used a three- dimensional, geometrically accurate finite element bidomain rabbit ventricular model. Transmural heterogeneities in ionic currents were incorporated based on experimental data to generate the transmural APD profile recorded in adult rabbits during pacing. Results show that the incorporation of transmural APD heterogeneities in the model causes an increase in the upper limit of vulnerability from 26.7 V/cm in the homogeneous APD ventricles to 30.5 V/cm in the ventricles with heterogeneous transmural APD profile. Examination of shock-end virtual electrode polarisation and postshock electrical activity reveals that the higher ULV in the heterogeneous model is caused by increased dispersion in postshock repolarisation within the LV wall, which increases the likelihood of the establishment of intramural re-entrant circuits.}, address = {Computing Laboratory, Oxford, UK. thum@comlab.ox.ac.uk}, author = {Maharaj, T. and Rodriguez, B. and Blake, R. and Trayanova, N. A. and Gavaghan, D. J.}, citeulike-article-id = {2547742}, citeulike-linkout-0 = {http://dx.doi.org/10.1109/IEMBS.2006.259345}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17946217}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17946217}, doi = {10.1109/IEMBS.2006.259345}, issn = {1557-170X}, journal = {Conf Proc IEEE Eng Med Biol Soc}, keywords = {me}, pages = {4043--4046}, posted-at = {2008-03-17 21:03:22}, priority = {2}, title = {Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability.}, url = {http://dx.doi.org/10.1109/IEMBS.2006.259345}, volume = {1}, year = {2006} }

TY - JOUR ID - citeulike:2547742 L3 - citeulike-article-id:2547742 N2 - Transmural dispersion in action potential duration (APD) has been shown to contribute to arrhythmia induction in the heart. However, its role in termination of lethal arrhythmias by defibrillation shocks has never been examined. The goal of this study is to investigate how transmural dispersion in APD affects cardiac vulnerability to electric shocks, in an attempt to better understand the mechanisms behind defibrillation failure. This study used a three- dimensional, geometrically accurate finite element bidomain rabbit ventricular model. Transmural heterogeneities in ionic currents were incorporated based on experimental data to generate the transmural APD profile recorded in adult rabbits during pacing. Results show that the incorporation of transmural APD heterogeneities in the model causes an increase in the upper limit of vulnerability from 26.7 V/cm in the homogeneous APD ventricles to 30.5 V/cm in the ventricles with heterogeneous transmural APD profile. Examination of shock-end virtual electrode polarisation and postshock electrical activity reveals that the higher ULV in the heterogeneous model is caused by increased dispersion in postshock repolarisation within the LV wall, which increases the likelihood of the establishment of intramural re-entrant circuits. JF - Conf Proc IEEE Eng Med Biol Soc SN - 1557-170X AD - Computing Laboratory, Oxford, UK. thum@comlab.ox.ac.uk EP - 4046 TI - Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability. VL - 1 SP - 4043 KW - me AU - Maharaj, T AU - Rodriguez, B AU - Blake, R AU - Trayanova, NA AU - Gavaghan, DJ PY - 2006/// UR - http://dx.doi.org/10.1109/IEMBS.2006.259345 ER -