Construction of tree models for pathogenesis of nasopharyngeal carcinoma.

@article{citeulike:2169731, abstract = {Pathogenesis of nasopharyngeal carcinoma (NPC) is a multistep and multipathway process that cannot be fully explained by a fixed linear progression model. We used distance-based and branching-tree methods to construct more general tree-like models for NPC carcinogenesis from 170 comparative genomic hybridization (CGH) samples previously published in five smaller studies. Imbalances were classified into "overlap regions," each containing the most commonly gained or lost band on each chromosome arm as well as adjacent bands that were gained or lost almost as often. The chromosome abnormalities associated with NPC were -3p26-13 (48.9\%), -11q22-25 (38.1\%), -16q12-24 (38.1\%), -14q24-32 (32.4\%), -13q21-32 (22.3\%), -9p23-21(21.6\%), +12p12 (46\%), +12q13-15 (43.9\%), +1q22-32 (33.1\%), +3q13.1-26.2 (30.2\%), and +8q22.1-24.2 (27.3\%). NPC can be classified into two groups, one marked by +12p12 and +8q22.1-24.2 and the other by -3p26-13, -11q22-25, -14q24-32, and +1q22-32. The tree models predicted -3p26-13 and +12p12 as early events and +8q22.1-24.2 as a late event. The predictions for -3p26-13 and +8q22.1-24.2 were consistent with previous studies. The prediction for +12p12 is being reported for the first time. Many known NPC-related genes on chromosomal regions of these tree models are discussed, some of which may merit additional study. The potential applications of tree models are also discussed.}, address = {Cancer Institute, Department of Pathology, First Military Medical University, Guangzhou, People's Republic of China.}, author = {Huang, Z. and Desper, R. and Sch\"{a}ffer, A. A. and Yin, Z. and Li, X. and Yao, K. }, citeulike-article-id = {2169731}, doi = {10.1002/gcc.20036}, issn = {1045-2257}, journal = {Genes Chromosomes Cancer}, month = {August}, number = {4}, pages = {307--315}, posted-at = {2007-12-26 10:51:45}, priority = {2}, title = {Construction of tree models for pathogenesis of nasopharyngeal carcinoma.}, url = {http://dx.doi.org/10.1002/gcc.20036}, volume = {40}, year = {2004} }

TY - JOUR ID - citeulike:2169731 L3 - citeulike-article-id:2169731 TI - Construction of tree models for pathogenesis of nasopharyngeal carcinoma. JF - Genes Chromosomes Cancer VL - 40 IS - 4 SP - 307 EP - 315 AD - Cancer Institute, Department of Pathology, First Military Medical University, Guangzhou, People's Republic of China. SN - 1045-2257 N2 - Pathogenesis of nasopharyngeal carcinoma (NPC) is a multistep and multipathway process that cannot be fully explained by a fixed linear progression model. We used distance-based and branching-tree methods to construct more general tree-like models for NPC carcinogenesis from 170 comparative genomic hybridization (CGH) samples previously published in five smaller studies. Imbalances were classified into "overlap regions," each containing the most commonly gained or lost band on each chromosome arm as well as adjacent bands that were gained or lost almost as often. The chromosome abnormalities associated with NPC were -3p26-13 (48.9%), -11q22-25 (38.1%), -16q12-24 (38.1%), -14q24-32 (32.4%), -13q21-32 (22.3%), -9p23-21(21.6%), +12p12 (46%), +12q13-15 (43.9%), +1q22-32 (33.1%), +3q13.1-26.2 (30.2%), and +8q22.1-24.2 (27.3%). NPC can be classified into two groups, one marked by +12p12 and +8q22.1-24.2 and the other by -3p26-13, -11q22-25, -14q24-32, and +1q22-32. The tree models predicted -3p26-13 and +12p12 as early events and +8q22.1-24.2 as a late event. The predictions for -3p26-13 and +8q22.1-24.2 were consistent with previous studies. The prediction for +12p12 is being reported for the first time. Many known NPC-related genes on chromosomal regions of these tree models are discussed, some of which may merit additional study. The potential applications of tree models are also discussed. AU - Huang, Z AU - Desper, R AU - Schäffer, AA AU - Yin, Z AU - Li, X AU - Yao, K PY - 2004/08// UR - http://dx.doi.org/10.1002/gcc.20036 ER -